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Cystatin A information


CSTA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSTA, AREI, STF1, STFA, Cystatin A, PSS4
External IDsOMIM: 184600; MGI: 1924020; HomoloGene: 3819; GeneCards: CSTA; OMA:CSTA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005213

NM_029733
NM_001384090

RefSeq (protein)

NP_005204

NP_084009
NP_001371019

Location (UCSC)Chr 3: 122.33 – 122.34 MbChr 16: 36.04 – 36.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cystatin-A is a protein that in humans is encoded by the CSTA gene.[5][6]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121552 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000095620 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hsieh WT, Barrick JL, Berrettini WH, Chan MM, Fong D (Jun 1991). "A PstI DNA polymorphism in the human stefin A gene (STF 1)". Nucleic Acids Res. 19 (7): 1722. doi:10.1093/nar/19.7.1722-a. PMC 333958. PMID 1674139.
  6. ^ a b "Entrez Gene: CSTA cystatin A (stefin A)".

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