CST2 information

CST2
Identifiers
Aliases	CST2, cystatin SA
External IDs	OMIM: 123856; GeneCards: CST2; OMA:CST2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	23,826,729 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; decidua; ; tongue; ; seminal vesicula; ; thalamus; ; thymus; ; right adrenal cortex; ; gallbladder; ; olfactory zone of nasal mucosa; ; gonad;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protein binding; protease binding; cysteine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of peptidase activity; detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of cysteine-type endopeptidase activity; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	1470
	n/a
	ENSG00000170369
	n/a
	P09228
	n/a
	NM_001322
	n/a
	NP_001313
	n/a
	Wikidata
View/Edit Human

Cystatin-SA is a protein that in humans is encoded by the CST2 gene.^[3]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma.^[3]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170369 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CST2 cystatin SA".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170369 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: CST2 cystatin SA".

CST2 information

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