negative regulation of extracellular matrix disassembly
regulation of tissue remodeling
negative regulation of blood vessel remodeling
negative regulation of elastin catabolic process
negative regulation of collagen catabolic process
neutrophil degranulation
supramolecular fiber organization
eye development
response to hypoxia
cell activation
apoptotic process
response to oxidative stress
brain development
salivary gland development
embryo implantation
positive regulation of cell population proliferation
male gonad development
response to toxic substance
response to carbohydrate
response to inorganic substance
response to organic cyclic compound
response to nutrient levels
response to estradiol
cellular response to oxidative stress
circadian sleep/wake cycle, REM sleep
regulation of programmed cell death
post-translational protein modification
positive regulation of DNA replication
response to axon injury
Sertoli cell development
negative regulation of cell death
cellular response to hydrogen peroxide
negative regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1471
13010
Ensembl
ENSG00000101439
ENSMUSG00000027447
UniProt
P01034
P21460
RefSeq (mRNA)
NM_001288614 NM_000099
NM_009976
RefSeq (protein)
NP_000090 NP_001275543
NP_034106
Location (UCSC)
Chr 20: 23.63 – 23.64 Mb
Chr 2: 148.71 – 148.72 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin, or neuroendocrine basic polypeptide),[5] a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition), such as Alzheimer's disease.
In humans, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and body fluids. It is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Cystatin C belongs to the type 2 cystatin gene family.
^ abcGRCh38: Ensembl release 89: ENSG00000101439 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027447 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Alzforum: AlzGene". Archived from the original on 2004-12-27.
CystatinC or cystatin 3 (formerly gamma trace, post-gamma-globulin, or neuroendocrine basic polypeptide), a protein encoded by the CST3 gene, is mainly...
these is cystatinC, a ubiquitous protein secreted by most cells in the body (it is an inhibitor of cysteine protease).[citation needed] CystatinC is freely...
described below. Cystatins show similarity to fetuins, kininogens, histidine-rich glycoproteins and cystatin-related proteins. Cystatins mainly inhibit...
Northern blot studies showed that cystatinC was produced by all nucleated human cells. The biological function of cystatinC was suggested to be inhibition...
Hereditary cystatinC amyloid angiopathy (HCCAA) is a rare, fatal type of hereditary cerebral amyloid angiopathy found almost exclusively in Iceland. A...
2-imino-1-methyl-5H-imidazol-4-ol) Creatinine starts to decompose around 300 °C. CystatinC, novel marker of kidney function Jaffe reaction, an example of creatinine...
diagnosed by checking the levels of several biomarkers such as clusterin and cystatinC. While the duration of ischemia was used as a biomarker, it was found...
Cystatin-A is a protein that in humans is encoded by the CSTA gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences...
measures, which involve clearance of such substrates as EDTA, iohexol, cystatinC, 125I-iothalamate (sodium radioiothalamate), the chromium radioisotope...
involving other amyloid peptides: the "Icelandic type" is associated with cystatinC amyloid (ACys). the "British type" and "Danish type" are associated with...
Cystatin-B is a protein that in humans is encoded by the CSTB gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences...
(Cockcroft-Gault Equation)- by MDCalc MDRD GFR Equation GFR calculator using CystatinC National Kidney Disease Education Program website. Includes professional...
Cystatin-SA is a protein that in humans is encoded by the CST2 gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like...
S2CID 25431033. Kyriakou P, Mouselimis D, Tsarouchas A, Rigopoulos A, Bakogiannis C, Noutsias M, Vassilikos V (December 2018). "Diagnosis of cardiac amyloidosis:...
alternative markers have been proposed (such as NGAL, KIM-1, IL18 and cystatinC), but none of them are established enough as of 2018 to replace creatinine...
stimulating collagen, interleukin 6, keratinocyte growth factor-1, IGF-1, cystatinC, tissue inhibitor of matrix metalloproteinases in the mouth. Current science...
with the length of the polyglutamine sequence, with analogous findings in a C. elegans model system with engineered polyglutamine peptides. Other polypeptides...
a complete blood count, a basic metabolic panel, and an assessment of cystatinc. Additionally, urodynamic testing and a kidney bladder ultrasound are...
(September 2003). "Grafting of features of cystatinsC or B into the N-terminal region or second binding loop of cystatin A (stefin A) substantially enhances...
diabetic nephropathy at earlier stages and identify progression risk. CystatinC is a protein that is freely filtered in the glomeruli before it is reabsorbed...
endogenous inhibitor, cystatinC, which also has a role in antigen presentation. Cystatin A and B have a lower activity compared to cystatinC. The active cleavage...
E. S.; Nichols, S. P.; Maylor, P. W. (1998). "Biological variation of cystatinC: Implications for the assessment of glomerular filtration rate". Clinical...
the glomerular filtration rate (GFR) of 5–30 kDa proteins, for example cystatinC, is selectively reduced compared to that of small molecules (less than...
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