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Creatinine information


Creatinine
Names
Preferred IUPAC name
2-Amino-1-methyl-5H-imidazol-4-one[citation needed]
Other names
2-Amino-1-methylimidazol-4-ol[citation needed]
Identifiers
CAS Number
  • 60-27-5 checkY
3D model (JSmol)
  • Interactive image
  • Interactive image
3DMet
  • B00175
Beilstein Reference
112061
ChEBI
  • CHEBI:16737 ☒N
ChEMBL
  • ChEMBL65567 ☒N
ChemSpider
  • 21640982 checkY
DrugBank
  • DB11846
ECHA InfoCard 100.000.424 Edit this at Wikidata
EC Number
  • 200-466-7
KEGG
  • D03600 checkY
MeSH Creatinine
PubChem CID
  • 26009888
  • 588 minor tautomer
UNII
  • AYI8EX34EU checkY
UN number 1789
CompTox Dashboard (EPA)
  • DTXSID8045987 Edit this at Wikidata
InChI
  • InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2,8H,1H3,(H2,5,6) checkY
    Key: BTXYOFGSUFEOLA-UHFFFAOYSA-N checkY
  • InChI=1/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)
    Key: DDRJAANPRJIHGJ-UHFFFAOYAV
SMILES
  • CN1CC(=O)N=C1N
  • CN1CC(=O)NC1=N
Properties
Chemical formula
C4H7N3O
Molar mass 113.120 g·mol−1
Appearance White crystals
Density 1.09 g cm−3
Melting point 300 °C (572 °F; 573 K)[1] (decomposes)
Solubility in water
1 part per 12[1]

90 mg/mL at 20°C[2]

log P -1.76
Acidity (pKa) 12.309
Basicity (pKb) 1.688
Isoelectric point 11.19
Thermochemistry
Heat capacity (C)
138.1 J K−1 mol−1 (at 23.4 °C)
Std molar
entropy (S298)
167.4 J K−1 mol−1
Std enthalpy of
formation fH298)
−240.81–239.05 kJ mol−1
Std enthalpy of
combustion cH298)
−2.33539–2.33367 MJ mol−1
Hazards
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
1
1
0
Flash point 290 °C (554 °F; 563 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Creatinine (/kriˈætɪnɪn, -nn/; from Ancient Greek: κρέας (kréas) 'flesh') is a breakdown product of creatine phosphate from muscle and protein metabolism. It is released at a constant rate by the body (depending on muscle mass).[3][4]

  1. ^ a b Merck Index, 11th Edition, 2571
  2. ^ "Creatinine, anhydrous - CAS 60-27-5". Scbt.com. Archived from the original on 2016-10-22. Retrieved 2016-10-21.
  3. ^ "Creatinine tests - Mayo Clinic". www.mayoclinic.org. Archived from the original on 2022-06-05.
  4. ^ Lewis SL, Bucher L, Heitkemper MM, Harding MM, Kwong J, Roberts D (September 2016). Medical-surgical nursing : assessment and management of clinical problems (10th ed.). St. Louis, Missouri: Elsevier Health Sciences. p. 1025. ISBN 978-0-323-37143-8. OCLC 228373703.

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Creatinine

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Creatinine (/kriˈætɪnɪn, -niːn/; from Ancient Greek: κρέας (kréas) 'flesh') is a breakdown product of creatine phosphate from muscle and protein metabolism...

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Glomerular filtration rate

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through the kidney. The creatinine clearance rate (CCr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful...

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Creatinine deaminase

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In enzymology, a creatinine deaminase (EC 3.5.4.21) is an enzyme that catalyzes the chemical reaction creatinine + H2O ⇌ {\displaystyle \rightleftharpoons...

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Microalbuminuria

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albumin in the sample against its concentration of creatinine is helpful. This is termed the albumin/creatinine ratio (ACR) and microalbuminuria is defined as...

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Basic metabolic panel

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called urea and electrolytes (U&E or "U and Es"), or urea, electrolytes, creatinine (UEC or EUC or CUE), and are often referred to as 'kidney function tests'...

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Assessment of kidney function

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the Bowman's capsule per unit time. Creatinine clearance is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure...

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Rilmenidine

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antihypertensive drugs. Hypertension. Severe depression, severe kidney failure (creatinine clearance <15 ml/min), as a precaution in the absence of currently available...

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Kidney failure

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combination of factors such as decreased urine production or increased serum creatinine. Diagnosis of chronic failure is based on a glomerular filtration rate...

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Blood urea nitrogen

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detect kidney problems. It is not considered as reliable as creatinine or BUN-to-creatinine ratio blood studies. BUN is an indication of kidney health...

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Proteinuria

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in the urine may be compared to the creatinine level in a spot urine sample. This is termed the protein/creatinine ratio. The 2005 UK Chronic Kidney Disease...

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Creatininase

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catalyses the hydrolysis of creatinine to creatine, which can then be metabolised to urea and sarcosine by creatinase. creatinine + H2O ⇌ {\displaystyle \rightleftharpoons...

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Azotemia

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abnormally high levels of nitrogen-containing compounds (such as urea, creatinine, various body waste compounds, and other nitrogen-rich compounds) in the...

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Birman

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concentration of creatinine and symmetric dimethylarginine, but most Birman cats have higher concentrations of creatinine than SDMA. Creatinine is a creatine...

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Creatine kinase

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is often listed in medical literature under incorrect name "creatinine kinase". Creatinine is not a substrate or a product of the enzyme. Reference ranges...

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Nephrology

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The serum creatinine concentration is the most important blood test as it is used to estimate the function of the kidney, called the creatinine clearance...

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Acute kidney injury

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function that develops within 7 days, as shown by an increase in serum creatinine or a decrease in urine output, or both. Causes of AKI are classified as...

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Uremia

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blood of amino acid and protein metabolism end products, such as urea and creatinine, which would be normally excreted in the urine. Uremic syndrome can be...

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Jaffe reaction

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reaction is a colorimetric method used in clinical chemistry to determine creatinine levels in blood and urine. In 1886, Max Jaffe (1841–1911) wrote about...

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Creatine

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κρέας (kreas). In 1928, creatine was shown to exist in equilibrium with creatinine. Studies in the 1920s showed that consumption of large amounts of creatine...

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Sulfamethoxazole

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people with creatinine clearance rates equal to or less than 30 mL/minute. A half-life of 22–50 hours has been reported for people with creatinine clearances...

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Trimethoprim

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(hyperkalemia). Can compete with creatinine for secretion into the renal tubule. This can cause an artificial rise in the serum creatinine. Use in EHEC infections...

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Blood test

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potassium, chloride, bicarbonate, blood urea nitrogen (BUN), magnesium, creatinine, glucose, and sometimes calcium. Tests that focus on cholesterol levels...

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Nephrotoxicity

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blood test. A decreased creatinine clearance indicates poor kidney function. In interventional radiology, a patient's creatinine clearance levels are all...

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Cystatin C

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studies have found cystatin C to be better in this regard than serum creatinine or creatinine-based GFR equations. Because the association of cystatin C with...

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Ramipril

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unilateral significant renal artery stenosis (RAS). An early rise in serum creatinine above baseline is expected after initiation of therapy with Ramipril,...

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Albuminuria

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increased urinary albumin/creatinine ratio (<30 mg/g or < 3 mg/mmol); A2 represents moderately increased urinary albumin/creatinine ratio (30–300 mg/g or...

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Chronic kidney disease

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derived from the serum creatinine and is proportional to 1/creatinine, i.e. it is a reciprocal relationship; the higher the creatinine, the lower the GFR...

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Inulin

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reasonably constant level in the plasma.: 228  In the United States, creatinine clearance is more widely used to estimate GFR. A 2017 systematic review...

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