positive regulation of cytosolic calcium ion concentration
cell-cell signaling
germinal center formation
regulation of angiogenesis
chemotaxis
endothelial cell chemotaxis to fibroblast growth factor
regulation of humoral immune response
cell surface receptor signaling pathway
response to lipopolysaccharide
regulation of cell population proliferation
defense response to bacterium
negative regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of T cell chemotaxis
immune response
inflammatory response
chronic inflammatory response
defense response
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
lymphocyte chemotaxis across high endothelial venule
positive regulation of integrin activation
positive regulation of cell-cell adhesion mediated by integrin
B cell chemotaxis
activation of GTPase activity
neutrophil chemotaxis
leukocyte chemotaxis
cellular response to lipopolysaccharide
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10563
55985
Ensembl
ENSG00000156234
ENSMUSG00000023078
UniProt
O43927
O55038
RefSeq (mRNA)
NM_006419 NM_001371558
NM_018866
RefSeq (protein)
NP_006410 NP_001358487
NP_061354
Location (UCSC)
Chr 4: 77.51 – 77.61 Mb
Chr 5: 96.1 – 96.11 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000156234 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023078 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.
^Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. Bibcode:1998Natur.391..799G. doi:10.1038/35876. PMID 9486651. S2CID 4373691.
Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand...
in turn, attract B cells with chemoattractant CXCL13. B cells lacking CXCR5, the receptor for CXCL13, still enter the white pulp, but are mislocalized...
(BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. It...
migration. These include: CCL14, CCL19, CCL20, CCL21, CCL25, CCL27, CXCL12 and CXCL13. This classification is not strict; for example, CCL20 can act also as pro-inflammatory...
CXCR5+CD8+T cells show a significant decrease of HBsAg. Also, an increase of CXCL13 levels facilitated the recruitment of intrahepatic CXCR5+CD8+T cells and...
lymphocytic leukemia cell chemotaxis towards the chemokines CXCL12 and CXCL13, and inhibit cellular adhesion following stimulation at the B-cell receptor...
response to pathogens. Th17 cells are involved in B cell recruitment through CXCL13 chemokine signaling, and Th17 activity may encourage antibody production...
lymphoid tissue structures. Their production is stimulated by retinoic acid, CXCL13, RANK-L, and the cytokines IL-1B, IL-23, and IL-6. They express c- Kit,...
the chemokine CCL21. and B cells exhibit CXCR5 receptors for chemokine CXCL13. The lymph from the peripheral tissues contains soluble antigens and arrives...
Global Information
