positive regulation of cytosolic calcium ion concentration
calcium-mediated signaling
cell chemotaxis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
643
12145
Ensembl
ENSG00000160683
ENSMUSG00000047880
UniProt
P32302
Q04683
RefSeq (mRNA)
NM_032966 NM_001716
NM_007551
RefSeq (protein)
NP_001707 NP_116743
NP_031577
Location (UCSC)
Chr 11: 118.88 – 118.9 Mb
Chr 9: 44.42 – 44.47 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. It enables T cells to migrate to lymph node and the B cell zones. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000160683 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000047880 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Dobner T, Wolf I, Emrich T, Lipp M (November 1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma". European Journal of Immunology. 22 (11): 2795–9. doi:10.1002/eji.1830221107. PMID 1425907. S2CID 35096818.
cell zones. In humans, the CXC-R5 protein is encoded by the CXCR5 gene. The BLR1 / CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic...
elicits its effects by interacting with chemokine receptor CXCR5. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid...
vascular endothelial cells and neuronal/nerve cells. The chemokine receptor CXCR5 is expressed on B cells and CD4+ Tfh cells and is involved in lymphocyte...
with CXCR5+CD8+T cells show a significant decrease of HBsAg. Also, an increase of CXCL13 levels facilitated the recruitment of intrahepatic CXCR5+CD8+T...
Among other homeostatic chemokine receptors include: CCR9, CCR10, and CXCR5, which are important as part of the cell addresses for tissue-specific homing...
BLRC (disambiguation) Burkitt lymphoma receptor 1 (BLR1), also known as CXCR5 This disambiguation page lists articles associated with the title BLR. If...
by their constitutive expression of the B cell follicle homing receptor CXCR5. Upon cellular interaction and cross-signaling with their cognate follicular...
in turn, attract B cells with chemoattractant CXCL13. B cells lacking CXCR5, the receptor for CXCL13, still enter the white pulp, but are mislocalized...
Suppression of p53 in human breast cancer cells is shown to lead to increased CXCR5 chemokine receptor gene expression and activated cell migration in response...
proteins like IRF4 commences production of Tfh indespensable molecules: CXCR5, ICOS, Bcl6 and IL-21. Tfh cells express high levels of NFATc1 and especially...
Müller G (2003). "Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking". Verhandlungen der Deutschen Gesellschaft für...
coreceptor (with CD4) for HIV-1 CD185 CXC chemokine receptor type 5, encoded by CXCR5 (or Burkitt lymphoma receptor 1, BLR1) gene; may have a regulatory function...
signaling pathways, including B-cell receptor (BCR) signaling and the CXCR4 and CXCR5 signaling, which are involved in the trafficking and homing of B-cells to...