Bromperidol, sold under the brand names Bromidol and Impromen among others, is a typical antipsychotic of the butyrophenone group which is used in the treatment of schizophrenia.[1][2] It was discovered at Janssen Pharmaceutica in 1966. An ester prodrug, bromperidol decanoate, is a long-acting form of bromperidol used as a depot injectable.[2]
v
t
e
Pharmacokinetics of long-acting injectable antipsychotics
Medication
Brand name
Class
Vehicle
Dosage
Tmax
t1/2 single
t1/2 multiple
logPc
Ref
Aripiprazole lauroxil
Aristada
Atypical
Watera
441–1064 mg/4–8 weeks
24–35 days
?
54–57 days
7.9–10.0
Aripiprazole monohydrate
Abilify Maintena
Atypical
Watera
300–400 mg/4 weeks
7 days
?
30–47 days
4.9–5.2
Bromperidol decanoate
Impromen Decanoas
Typical
Sesame oil
40–300 mg/4 weeks
3–9 days
?
21–25 days
7.9
[3]
Clopentixol decanoate
Sordinol Depot
Typical
Viscoleob
50–600 mg/1–4 weeks
4–7 days
?
19 days
9.0
[4]
Flupentixol decanoate
Depixol
Typical
Viscoleob
10–200 mg/2–4 weeks
4–10 days
8 days
17 days
7.2–9.2
[4][5]
Fluphenazine decanoate
Prolixin Decanoate
Typical
Sesame oil
12.5–100 mg/2–5 weeks
1–2 days
1–10 days
14–100 days
7.2–9.0
[6][7][8]
Fluphenazine enanthate
Prolixin Enanthate
Typical
Sesame oil
12.5–100 mg/1–4 weeks
2–3 days
4 days
?
6.4–7.4
[7]
Fluspirilene
Imap, Redeptin
Typical
Watera
2–12 mg/1 week
1–8 days
7 days
?
5.2–5.8
[9]
Haloperidol decanoate
Haldol Decanoate
Typical
Sesame oil
20–400 mg/2–4 weeks
3–9 days
18–21 days
7.2–7.9
[10][11]
Olanzapine pamoate
Zyprexa Relprevv
Atypical
Watera
150–405 mg/2–4 weeks
7 days
?
30 days
–
Oxyprothepin decanoate
Meclopin
Typical
?
?
?
?
?
8.5–8.7
Paliperidone palmitate
Invega Sustenna
Atypical
Watera
39–819 mg/4–12 weeks
13–33 days
25–139 days
?
8.1–10.1
Perphenazine decanoate
Trilafon Dekanoat
Typical
Sesame oil
50–200 mg/2–4 weeks
?
?
27 days
8.9
Perphenazine enanthate
Trilafon Enanthate
Typical
Sesame oil
25–200 mg/2 weeks
2–3 days
?
4–7 days
6.4–7.2
[12]
Pipotiazine palmitate
Piportil Longum
Typical
Viscoleob
25–400 mg/4 weeks
9–10 days
?
14–21 days
8.5–11.6
[5]
Pipotiazine undecylenate
Piportil Medium
Typical
Sesame oil
100–200 mg/2 weeks
?
?
?
8.4
Risperidone
Risperdal Consta
Atypical
Microspheres
12.5–75 mg/2 weeks
21 days
?
3–6 days
–
Zuclopentixol acetate
Clopixol Acuphase
Typical
Viscoleob
50–200 mg/1–3 days
1–2 days
1–2 days
4.7–4.9
Zuclopentixol decanoate
Clopixol Depot
Typical
Viscoleob
50–800 mg/2–4 weeks
4–9 days
?
11–21 days
7.5–9.0
Note: All by intramuscular injection. Footnotes:a = Microcrystalline or nanocrystalline aqueous suspension. b = Low-viscosity vegetable oil (specifically fractionated coconut oil with medium-chain triglycerides). c = Predicted, from PubChem and DrugBank. Sources:Main: See template.
^J. Elks, ed. (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 182–. ISBN 978-1-4757-2085-3. OCLC 1058412474.
^ abSwiss Pharmaceutical Society (2000). Swiss Pharmaceutical Society (ed.). Index Nominum 2000: International Drug Directory. Taylor & Francis. pp. 138–. ISBN 978-3-88763-075-1.
^Parent M, Toussaint C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation". Current Therapeutic Research. 34 (1): 1–6.
^ abJørgensen A, Overø KF (1980). "Clopenthixol and flupenthixol depot preparations in outpatient schizophrenics. III. Serum levels". Acta Psychiatrica Scandinavica. Supplementum. 279: 41–54. doi:10.1111/j.1600-0447.1980.tb07082.x. PMID 6931472.
^ abReynolds JE (1993). "Anxiolytic sedatives, hypnotics and neuroleptics.". Martindale: The Extra Pharmacopoeia (30th ed.). London: Pharmaceutical Press. pp. 364–623.
^Ereshefsky L, Saklad SR, Jann MW, Davis CM, Richards A, Seidel DR (May 1984). "Future of depot neuroleptic therapy: pharmacokinetic and pharmacodynamic approaches". The Journal of Clinical Psychiatry. 45 (5 Pt 2): 50–9. PMID 6143748.
^ abCurry SH, Whelpton R, de Schepper PJ, Vranckx S, Schiff AA (April 1979). "Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man". British Journal of Clinical Pharmacology. 7 (4): 325–31. doi:10.1111/j.1365-2125.1979.tb00941.x. PMC 1429660. PMID 444352.
^Young D, Ereshefsky L, Saklad SR, Jann MW, Garcia N (1984). Explaining the pharmacokinetics of fluphenazine through computer simulations. (Abstract.). 19th Annual Midyear Clinical Meeting of the American Society of Hospital Pharmacists. Dallas, Texas.
^Janssen PA, Niemegeers CJ, Schellekens KH, Lenaerts FM, Verbruggen FJ, van Nueten JM, Marsboom RH, Hérin VV, Schaper WK (November 1970). "The pharmacology of fluspirilene (R 6218), a potent, long-acting and injectable neuroleptic drug". Arzneimittel-Forschung. 20 (11): 1689–98. PMID 4992598.
^Beresford R, Ward A (January 1987). "Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis". Drugs. 33 (1): 31–49. doi:10.2165/00003495-198733010-00002. PMID 3545764.
^Reyntigens AJ, Heykants JJ, Woestenborghs RJ, Gelders YG, Aerts TJ (1982). "Pharmacokinetics of haloperidol decanoate. A 2-year follow-up". International Pharmacopsychiatry. 17 (4): 238–46. doi:10.1159/000468580. PMID 7185768.
^Larsson M, Axelsson R, Forsman A (1984). "On the pharmacokinetics of perphenazine: a clinical study of perphenazine enanthate and decanoate". Current Therapeutic Research. 36 (6): 1071–88.
Bromperidol, sold under the brand names Bromidol and Impromen among others, is a typical antipsychotic of the butyrophenone group which is used in the...
Bromperidol decanoate, sold under the brand names Bromidol Depot, Bromodol Decanoato, and Impromen Decanoas, is an antipsychotic which has been marketed...
Following is a list of antipsychotics, sorted by class. Bromperidol decanoate Clopenthixol decanoate Flupentixol decanoate Flupentixol palmitate Fluphenazine...
C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation". Current Therapeutic...
C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation". Current Therapeutic...
v t e Antipsychotics (N05A) Typical Butyrophenones: Benperidol BromperidolBromperidol decanoate Droperidol Haloperidol# Haloperidol decanoate Moperone...
v t e Antipsychotics (N05A) Typical Butyrophenones: Benperidol BromperidolBromperidol decanoate Droperidol Haloperidol# Haloperidol decanoate Moperone...
C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation". Current Therapeutic...
v t e Antipsychotics (N05A) Typical Butyrophenones: Benperidol BromperidolBromperidol decanoate Droperidol Haloperidol# Haloperidol decanoate Moperone...
v t e Antipsychotics (N05A) Typical Butyrophenones: Benperidol BromperidolBromperidol decanoate Droperidol Haloperidol# Haloperidol decanoate Moperone...
C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation". Current Therapeutic...
C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation". Current Therapeutic...
C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation". Current Therapeutic...
v t e Antipsychotics (N05A) Typical Butyrophenones: Benperidol BromperidolBromperidol decanoate Droperidol Haloperidol# Haloperidol decanoate Moperone...
C, Gilson H (1983). "Long-term treatment of chronic psychotics with bromperidol decanoate: clinical and pharmacokinetic evaluation". Current Therapeutic...