In biochemistry and metabolism, beta oxidation (also β-oxidation) is the catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA. Acetyl-CoA enters the citric acid cycle, generating NADH and FADH2, which are electron carriers used in the electron transport chain. It is named as such because the beta carbon of the fatty acid chain undergoes oxidation and is converted to a carbonyl group to start the cycle all over again. Beta-oxidation is primarily facilitated by the mitochondrial trifunctional protein, an enzyme complex associated with the inner mitochondrial membrane, although very long chain fatty acids are oxidized in peroxisomes.
The overall reaction for one cycle of beta oxidation is:
In biochemistry and metabolism, betaoxidation (also β-oxidation) is the catabolic process by which fatty acid molecules are broken down in the cytosol...
cycle, and oxidative phosphorylation equals about 30 ATP molecules, in eukaryotes. The number of ATP molecules derived from the betaoxidation of a 6 carbon...
mitochondria membrane and enter the process of betaoxidation. The main products of the betaoxidation pathway are acetyl-CoA (which is used in the citric...
eukaryotes are (1) glycolysis, (2) the citric acid cycle/oxidative phosphorylation, and (3) beta-oxidation. The overall process of oxidizing glucose to carbon...
Oxidative phosphorylation (UK /ɒkˈsɪd.ə.tɪv/, US /ˈɑːk.sɪˌdeɪ.tɪv/ ) or electron transport-linked phosphorylation or terminal oxidation is the metabolic...
synthesis of nucleotides. While the pentose phosphate pathway does involve oxidation of glucose, its primary role is anabolic rather than catabolic. The pathway...
Alpha oxidation (α-oxidation) is a process by which certain branched-chain fatty acids are broken down by removal of a single carbon from the carboxyl...
spontaneously. These ATPs are supplied from fatty acid catabolism via betaoxidation. In humans the main gluconeogenic precursors are lactate, glycerol (which...
specific, low Km transporter to bring it into the mitochondrial matrix for oxidation by the pyruvate dehydrogenase complex. The phosphate carrier (PiC) mediates...
through a beta-oxidative pathway or a non-beta-oxidative pathway. The beta-oxidative pathway produces benzoyl-CoA while the non-beta-oxidative pathway produces...
ketones can be ineffective in people with defects in the pathway for beta-oxidation, in the genes for ketogenesis (HMGCS2 and HMGCL), for ketolysis (OXCT1...
glycolysis, as it is in most other energy yielding metabolic reactions (e.g. beta-oxidation of fatty acids, and during the citric acid cycle). The NADH thus produced...
Ketolysis provides more energy for ATP synthesis than fatty acid oxidation (betaoxidation). Ketogenesis occurs primarily in the liver, whereas ketolysis...
spontaneously. These ATPs are supplied from fatty acid catabolism via betaoxidation. Glycogenolysis refers to the breakdown of glycogen. In the liver, muscles...
broken down by betaoxidation to release acetyl-CoA, which then is fed into the citric acid cycle. Fatty acids release more energy upon oxidation than carbohydrates...
catalyzes three out of the four steps in betaoxidation. MTP is a hetero-octamer composed of four alpha and four beta subunits: HADHA HADHB The three functions...
The carnitine palmitoyltransferase system is an essential step in the beta-oxidation of long chain fatty acids. This transfer system is necessary because...
result of fatty acid buildup caused by failure of peroxisomal fatty acid betaoxidation which results in the accumulation of very long chain fatty acids in...
the reducing agent is NADPH, whereas NAD is the oxidizing agent in beta-oxidation (the breakdown of fatty acids to acetyl-CoA). This difference exemplifies...
an energy source by vertebrates as fatty acids are degraded through betaoxidation into acetate molecules. This acetate, bound to the active thiol group...
Oxidization may refer to: Oxidation, a chemical reaction in which electrons are lost Betaoxidation, the process by which fatty acids are broken down...
example, in homofermentative lactic acid bacteria, NADH formed during the oxidation of glyceraldehyde-3-phosphate is oxidized back to NAD+ by the reduction...
of ATP, such as the citric acid cycle, oxidative phosphorylation, oxidation of pyruvate, and the betaoxidation of fatty acids. The composition of the...
impaired very long chain fatty acid beta-oxidation, phytanic acid alpha-oxidation, pristanic acid alpha-oxidation, and plasmalogen biosynthesis. The nutrient...
data. This gene encodes the beta subunit of the mitochondrial trifunctional protein, a catalyst of mitochondrial beta-oxidation of long chain fatty acids...
NADPH-dependent and NADPH-independent pathways of beta-oxidation. The double bond serves as the target of oxidation and carbon-to-carbon bond cleavage, thereby...
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