Chemical compound
Aplindore ATC code
(2S )-2-[(phenylmethylamino)methyl]-2,3,7,9-tetrahydro-[1,4]dioxino[3,2-e]indol-8-one
CAS Number 189681-70-7 Y fumarate: 189681-71-8 Y PubChem CID ChemSpider 139676 Y UNII Q5O76TA0ML fumarate: P13TV5A758 Y KEGG D03214 Y ChEMBL ChEMBL2110659 N CompTox Dashboard (EPA ) DTXSID60870185 Formula C 18 H 18 N 2 O 3 Molar mass 310.353 g·mol−1 3D model (JSmol)
c4ccccc4CNCC(CO2)Oc1c2ccc(N3)c1CC3=O
InChI=1S/C18H18N2O3/c21-17-8-14-15(20-17)6-7-16-18(14)23-13(11-22-16)10-19-9-12-4-2-1-3-5-12/h1-7,13,19H,8-11H2,(H,20,21)/t13-/m0/s1
Y Key:DYJIKHYBKVODAC-ZDUSSCGKSA-N
Y
N Y (what is this?) (verify)
Aplindore (DAB-452 ) is a drug which acts as a partial agonist selective for the dopamine receptor D2.[1] It is being developed by the pharmaceutical company Neurogen as a treatment for Parkinson's disease and restless legs syndrome.
On December 23, 2009 Neurogen was acquired by Ligand Pharmaceuticals. Rights to Aplindore were given to Ligand around time of merger. As of 2008, Phase II was completed and Ligand.
Upon reviewing company website (Ligand.com) this drug is currently not listed at the moment due to several programs already partnered with GSK. GSK holds a significant share of the drug RLS drug programs on the market with Requip XR and the recent FDA approval of Horizant. To prevent any direct competition and losing strong ties with GSK, Aplindore is not listed at the moment on Lidgand website. If this medication were to reach phase III, this could adversely effect Ligand`s portfolio of partnered and unpartnered assets. By electing not to list the drug on company website, Ligand maintains the appearance that they are "currently actively seeking a partner" when a potential investor inquirers about drug development via email.
^ Heinrich JN, Brennan J, Lai MH, Sullivan K, Hornby G, Popiolek M, Jiang LX, Pausch MH, Stack G, Marquis KL, Andree TH (December 2006). "Aplindore (DAB-452), a high affinity selective dopamine D2 receptor partial agonist". European Journal of Pharmacology . 552 (1–3): 36–45. doi:10.1016/j.ejphar.2006.08.063. PMID 17056032.
Last Update: 2022-11-13T20:14:38Z
Aplindore (DAB-452) is a drug which acts as a partial agonist selective for the dopamine receptor D2. It is being developed by the pharmaceutical company...
Word Count : 242
Last Update: 2024-06-15T16:22:11Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 11401
Last Update: 2024-06-07T10:09:37Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 16718
Last Update: 2024-06-17T03:46:40Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 5488
Last Update: 2024-06-12T04:17:49Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 15614
Last Update: 2024-04-02T05:19:08Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 6534
Last Update: 2024-06-10T21:45:31Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 9106
Last Update: 2024-05-31T02:33:06Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 2385
Last Update: 2024-05-25T11:10:50Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 2681
Last Update: 2024-06-03T17:01:24Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 14161
Last Update: 2024-06-11T16:11:45Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 11783
Last Update: 2024-05-24T17:48:58Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 8668
Last Update: 2024-06-19T09:26:12Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 5314
Last Update: 2024-05-25T02:04:04Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 3708
Last Update: 2024-05-20T13:48:36Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 5041
Last Update: 2023-12-19T21:21:39Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 1748
Last Update: 2024-06-04T00:52:47Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 3754
Last Update: 2024-04-26T23:03:45Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 3454
Last Update: 2024-05-25T02:25:35Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 4889
Last Update: 2024-05-25T02:00:20Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 5296
Last Update: 2024-04-21T09:39:58Z
Doxanthrine Others: A-68,930 • A-77,636 • A-412,997 • ABT-670 • ABT-724 • Aplindore • Apomorphine • Aripiprazole • Azodopa • Bifeprunox • BP-897 • CY-208...
Word Count : 831
Last Update: 2023-12-03T13:12:20Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 315
Last Update: 2024-05-14T00:33:04Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 1804
Last Update: 2024-05-18T06:03:21Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 2618
Last Update: 2023-12-24T06:01:07Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 589
Last Update: 2024-04-27T11:23:32Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 1943
Last Update: 2024-06-08T16:15:35Z
Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine...
Word Count : 5979