Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities.[3][4] Generally it is used together with dietary changes and a statin.[5] Alone, it is less preferred than a statin.[4] It is taken by mouth.[4] It is also available in the fixed combinations ezetimibe/simvastatin,[6] ezetimibe/atorvastatin,[7] ezetimibe/rosuvastatin,[4][8] and ezetimibe/bempedoic acid.[9]
The most commonly reported adverse events include upper respiratory tract infections, joint pain, diarrhea, and tiredness.[4] Serious side effects may include anaphylaxis, liver problems, depression, and muscle breakdown.[4][5] Use in pregnancy and breastfeeding is of unclear safety.[10] Ezetimibe works by decreasing cholesterol absorption in the intestines.[5]
Ezetimibe was approved for medical use in the United States in 2002.[4] It is available as a generic medication.[5] In 2021, it was the 92nd most commonly prescribed medication in the United States, with more than 7million prescriptions.[11][12]
^ ab"AusPAR: Ezetimibe". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 20 April 2024.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^ ab"Zetia- ezetimibe tablet". DailyMed. 26 January 2011. Archived from the original on 10 May 2021. Retrieved 13 August 2022.
^ abcdefg"Ezetimibe Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 13 April 2019.
^ abcdBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 196. ISBN 9780857113382.
^"Vytorin- ezetimibe and simvastatin tablet". DailyMed. 1 June 2022. Archived from the original on 14 August 2022. Retrieved 13 August 2022.
^"Liptruzet (ezetimibe and atorvastatin) tablets for oral useInitial U.S. Approval: 2013". DailyMed. 30 September 2016. Archived from the original on 14 August 2022. Retrieved 13 August 2022.
^"Roszet- rosuvastatin and ezetimibe tablet Roszet (- rosuvastatin and ezetimibe tablet". DailyMed. 15 September 2021. Archived from the original on 14 August 2022. Retrieved 13 August 2022.
^"Nexlizet- bempedoic acid and ezetimibe tablet, film coated". DailyMed. 24 September 2021. Retrieved 13 August 2022.
^"Ezetimibe (Zetia) Use During Pregnancy". Drugs.com. Archived from the original on 13 April 2019. Retrieved 13 April 2019.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Ezetimibe - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
available in the fixed combinations ezetimibe/simvastatin, ezetimibe/atorvastatin, ezetimibe/rosuvastatin, and ezetimibe/bempedoic acid. The most commonly...
appears to bind to a critical mediator of cholesterol absorption. The drug ezetimibe inhibits NPC1L1 causing a reduction in cholesterol absorption, resulting...
(brand name Nilemdo) and as a fixed-dose combination medication with ezetimibe (brand name Nustendi). Bempedoic acid was approved for use in the European...
it is used as a lipid-lowering agent and it has efficacy similar to ezetimibe. Ruan Z, Jiang B, Chen J, Zhang X, Lou H, Xiang M, et al. (October 2014)...
simvastatin. Combination preparations of a statin and another agent, such as ezetimibe/simvastatin, are also available. The class is on the World Health Organization's...
showed that these agents also reduced the risk of cardiovascular events. Ezetimibe inhibits the intestinal absorption of cholesterol and can be used alone...
study suggested that LDL cholesterol-lowering treatments (e.g. statin/ezetimibe combination) are effective in reducing the risks of major atherosclerotic...
digested and absorbed, sometimes causing oily anal leakage. Vytorin (ezetimibe/simvastatin) tablets can cause steatorrhea in some people. Some studies...
Na JO (September 2019). "Pharmacological Strategies beyond Statins: Ezetimibe and PCSK9 Inhibitors". Journal of Lipid and Atherosclerosis. 8 (2): 183–191...
"Alopecia Universalis: Hair Growth following Initiation of Simvastatin and Ezetimibe Therapy". Journal of Drugs in Dermatology. 6 (9): 946–7. PMID 17941369...
Medicines that inhibit cholesterol absorption in the small intestine, such as Ezetimibe, may be effective treatments in some patients. An anti-filarial drug,...
familial hypercholesterolemia. Treatment may include, niacin or statin or ezetimibe.: 534 It is also known as "normotriglyceridemic hypobetalipoproteinemia"...
high permeability, low solubility Example: glibenclamide, bicalutamide, ezetimibe, aceclofenac The bioavailability of those products is limited by their...
sold in the EU) Nustendi (fixed dose combination of bempedoic acid and ezetimibe) Other Canalia (teneligliptin, canagliflozin) (available only in Japan)...
the condition is highly effective with a class of lipid lowering agent: Ezetimibe. Polygenic hypercholesterolemia can also involve neurological or psychiatric...
rosuvastatin are atorvastatin and simvastatin. However, people can also combine ezetimibe with either simvastatin or atorvastatin and other agents on their own...
Davidson, Michael H.; Nicholls, Stephen J. (July 2023). "Obicetrapib plus ezetimibe as an adjunct to high-intensity statin therapy: A randomized phase 2 trial"...
should be commenced to lower LDL cholesterol. Other medications, such as ezetimibe, may also be added with this goal in mind. Aldosterone antagonists (spironolactone...
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