Global InformationHPG80 information
 | The topic of this article may not meet Wikipedia's notability guideline for neologisms. (August 2020) |
hPG80 refers to the extracellular and oncogenic version of progastrin. This name first appeared in a scientific publication in January 2020.[1] Until that date, scientific publications only mention 'progastrin', without necessarily explicitly specifying whether it is intracellular (in the context of digestion) or extracellular (circulating and detectable in plasma) in the tumor pathological setting.
For more clarity, the remainder of this article uses exclusively the name hPG80 to refer to extracellular progastrin.
A link between this protein and cancer has been known for more than 30 years. hPG80 is involved in most of the biological functions that ensure the existence of cancer.[2] The peptide is secreted by tumor cells and found in the plasma of cancer patients from early stages.[1] It then has functions that are independent of digestion and totally different from progastrin and its only role as an intracellular precursor of gastrin.
- ^ a b You, Benoit; Mercier, Frédéric; Assenat, Eric; Langlois-Jacques, Carole; Glehen, Olivier; Soulé, Julien; Payen, Léa; Kepenekian, Vahan; Dupuy, Marie; Belouin, Fanny; Morency, Eric (January 2020). "The oncogenic and druggable hPG80 (Progastrin) is overexpressed in multiple cancers and detected in the blood of patients". eBioMedicine. 51: 102574. doi:10.1016/j.ebiom.2019.11.035. ISSN 2352-3964. PMC 6938867. PMID 31877416.
- ^ Hollande, F. (2003-04-01). "Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells". Journal of Cell Science. 116 (7): 1187–1197. doi:10.1242/jcs.00321. PMID 12615962. S2CID 21931954.