purine-specific mismatch base pair DNA N-glycosylase activity
DNA polymerase processivity factor activity
Cellular component
nucleus
replisome
nucleoplasm
extracellular exosome
DNA replication factor C complex
centrosome
PCNA complex
nuclear replication fork
PCNA-p21 complex
replication fork
nuclear body
chromatin
Biological process
replication fork processing
translesion synthesis
DNA replication
nucleotide-excision repair, DNA gap filling
protein sumoylation
regulation of DNA replication
transcription-coupled nucleotide-excision repair
positive regulation of deoxyribonuclease activity
nucleotide-excision repair, DNA incision
error-free translesion synthesis
positive regulation of DNA repair
regulation of transcription involved in G1/S transition of mitotic cell cycle
positive regulation of DNA replication
response to lipid
heart development
DNA mismatch repair
cellular response to DNA damage stimulus
mitotic telomere maintenance via semi-conservative replication
epithelial cell differentiation
response to cadmium ion
cell population proliferation
telomere maintenance
error-prone translesion synthesis
cellular response to UV
estrous cycle
cellular response to hydrogen peroxide
response to dexamethasone
nucleotide-excision repair, DNA incision, 5'-to lesion
liver regeneration
response to estradiol
response to oxidative stress
DNA repair
response to L-glutamate
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
DNA ligation
leading strand elongation
protein ubiquitination
telomere maintenance via semi-conservative replication
viral process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5111
18538
Ensembl
ENSG00000132646
ENSMUSG00000027342
UniProt
P12004
P17918
RefSeq (mRNA)
NM_182649 NM_002592
NM_011045
RefSeq (protein)
NP_002583 NP_872590
NP_035175
Location (UCSC)
Chr 20: 5.11 – 5.13 Mb
Chr 2: 132.09 – 132.1 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cryo-EM structure of the DNA-bound PolD–PCNA processive complex
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.[5]
Many proteins interact with PCNA via the two known PCNA-interacting motifs PCNA-interacting peptide (PIP) box[6] and AlkB homologue 2 PCNA interacting motif (APIM).[7] Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM are mainly important in the context of genotoxic stress.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000132646 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027342 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Moldovan GL, Pfander B, Jentsch S (May 2007). "PCNA, the maestro of the replication fork". Cell. 129 (4): 665–679. doi:10.1016/j.cell.2007.05.003. PMID 17512402. S2CID 3547069.
^Warbrick E (March 1998). "PCNA binding through a conserved motif". BioEssays. 20 (3): 195–199. doi:10.1002/(sici)1521-1878(199803)20:3<195::aid-bies2>3.0.co;2-r. PMID 9631646.
^Gilljam KM, Feyzi E, Aas PA, Sousa MM, Müller R, Vågbø CB, et al. (September 2009). "Identification of a novel, widespread, and functionally important PCNA-binding motif". The Journal of Cell Biology. 186 (5): 645–654. doi:10.1083/jcb.200903138. PMC 2742182. PMID 19736315.
^Mailand N, Gibbs-Seymour I, Bekker-Jensen S (May 2013). "Regulation of PCNA-protein interactions for genome stability". Nature Reviews. Molecular Cell Biology. 14 (5): 269–282. doi:10.1038/nrm3562. PMID 23594953. S2CID 25952152.
and 28 Related for: Proliferating cell nuclear antigen information
Proliferatingcellnuclearantigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for...
polymerase α, DNA polymerase ε, replication protein A (RPA) and proliferatingcellnuclearantigen (PCNA) onto chromatin. Within a Xenopus nucleus-free system...
anticancer medication which acts as a small molecule inhibitor of proliferatingcellnuclearantigen (PCNA) and is in Phase I clinical trials at City of Hope as...
from a specific subunit of DNA polymerase delta called the proliferatingcellnuclearantigen (PCNA). The N-terminal and C-terminal domains of PCNA are...
failures could be lethal to the cell. Further research implicates the supplementary role of proliferatingcellnuclearantigen (PCNA) to DNA ligase I's function...
activity via ubiquitin ligase activity. p21 interacts with proliferatingcellnuclearantigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory...
for RFC-dependent loading of the replication sliding clamp, proliferatingcellnuclearantigen (PCNA), in an orientation-specific manner, such that one face...
bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins...
exhibits increased processivity when interacting with the proliferatingcellnuclearantigen (PCNA). As well, the multisubunit protein replication factor...
Conversion from mitosis to meiosis: morphology and expression of proliferatingcellnuclearantigen (PCNA) and Dmc1 during newt spermatogenesis. Dev Growth Differ...
synthesis by DNA polymerase epsilon in the presence of PCNA (proliferatingcellnuclearantigen), RFC (replication factor C) and RPA (replication protein...
Similarly, proliferatingcellnuclearantigen (PCNA) is a protein associated with cell proliferation that is upregulated in proliferatingcells, making it...
AA, et al. (December 2001). "UV-induced DNA incision and proliferatingcellnuclearantigen recruitment to repair sites occur independently of p53-replication...
topoisomerase II A, the FLAP endonuclease and the processing factor proliferatingcellnuclearantigen. Other proteins include DNA dependent RNA polymerase II and...
DNA damage 45alpha (Gadd45alpha) and its interactions with proliferatingcellnuclearantigen (PCNA) and Aurora A kinase". J. Biol. Chem. 285 (29): 22196–201...
dimerization, allowing MutSβ to bind to DNA and perform MMR. Proliferatingcellnuclearantigen (PCNA) is a protein involved in post-replication MMR. It has...
2002). "A proteomics approach to identify proliferatingcellnuclearantigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5...
polymerases. A bypass platform is provided to these polymerases by Proliferatingcellnuclearantigen (PCNA). Under normal circumstances, PCNA bound to polymerases...
and epsilon requires the action of the accessory proteins, proliferatingcellnuclearantigen (PCNA) and replication factor C (RFC). RFC, also called activator...
whale's ability to live longer are the ERCC1 gene and the proliferatingcellnuclearantigen (PCNA) gene. ERCC1 is linked to DNA repair and increased cancer...
each B cell can produce antibodies containing only one kind of variable chain. Following activation with antigen, B cells begin to proliferate rapidly...
somatic cells, localizes to replication foci, has a 10–40-fold preference for hemimethylated DNA and interacts with the proliferatingcellnuclearantigen (PCNA)...
the repair process. Replication factor C (RFC) loads the ProliferatingCellNuclearAntigen (PCNA) onto the DNA strand. This allows DNA polymerases implicated...
organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to...
strand by PCNA (ProliferatingCellNuclearAntigen). PCNA forms typical patterns in the nucleus of the cell through which the current cell cycle can be determined...
2002). "A proteomics approach to identify proliferatingcellnuclearantigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5...
Global Information
