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Vomocytosis information


Vomocytosis (sometimes called non-lytic expulsion) is the cellular process by phagocytes expel live organisms that they have engulfed without destroying the organism. Vomocytosis is one of many methods used by cells to expel internal materials into their external environment, yet it is distinct in that both the engulfed organism and host cell remain undamaged by expulsion. As engulfed organisms are released without being destroyed, vomocytosis has been hypothesized to be utilized by pathogens as an escape mechanism from the immune system. The exact mechanisms, as well as the repertoire of cells that utilize this mechanism, are currently unknown, yet interest in this unique cellular process is driving continued research with the hopes of elucidating these unknowns.

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Vomocytosis

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enhancing vomocytosis. Additionally, the phagosomal pH may play important roles in vomocytosis efficacy as research has demonstrated vomocytosis rates drop...

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Cryptococcus neoformans

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intracellular pathogen for which the non-lytic escape process termed vomocytosis was observed. It has been speculated that this ability to manipulate...

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Arturo Casadevall

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Robin May, his group were the first to observe non-lytic expulsion, or vomocytosis, of intracellular fungi. Subsequently, with Kirsten Nielsen at the University...

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