Adjacent repeated pattern of nucleotides within DNA
Not to be confused with Tandemly arrayed genes.
In genetics, tandem repeats occur in DNA when a pattern of one or more nucleotides is repeated and the repetitions are directly adjacent to each other, e.g. ATTCG ATTCG ATTCG, in which the sequence ATTCG is repeated three times.[1]
Several protein domains also form tandem repeats within their amino acid primary structure, such as armadillo repeats. However, in proteins, perfect tandem repeats are rare in naturally proteins, but they have been added to designed proteins.[2]
Tandem repeats constitute ~6% of the human genome. They are implicated in more than 50 lethal human diseases, including amyotrophic lateral sclerosis, Huntington's disease, and several cancers.[3]
^Tandem+Repeat at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
^Jorda J, Xue B, Uversky VN, Kajava AV (June 2010). "Protein tandem repeats - the more perfect, the less structured". The FEBS Journal. 277 (12): 2673–82. doi:10.1111/j.1742-4658.2010.07684.x. PMC 2928880. PMID 20553501.
^Cui, Ya; Ye, Wenbin; Li, Jason Sheng; Li, Jingyi Jessica; Vilain, Eric; Sallam, Tamer; Li, Wei (April 2024). "A genome-wide spectrum of tandem repeat expansions in 338,963 humans". Cell. 187 (9): 2336–2341.e5. doi:10.1016/j.cell.2024.03.004. ISSN 0092-8674.
In genetics, tandemrepeats occur in DNA when a pattern of one or more nucleotides is repeated and the repetitions are directly adjacent to each other...
often referred to as short tandemrepeats (STRs) by forensic geneticists and in genetic genealogy, or as simple sequence repeats (SSRs) by plant geneticists...
variable number tandemrepeat (or VNTR) is a location in a genome where a short nucleotide sequence is organized as a tandemrepeat. These can be found...
An array of protein tandemrepeats is defined as several (at least two) adjacent copies having the same or similar sequence motifs. These periodic sequences...
Variable number of tandemrepeat locus (VNTR locus) is any DNA sequence that exist in multiple copies strung together in a variety of tandem lengths. The number...
Short tandemrepeat (STR) analysis is a common molecular biology method used to compare allele repeats at specific loci in DNA between two or more samples...
while the proximity of the repeat sequences varies between widely dispersed and simple tandem arrays. The short tandemrepeat sequences may exist as just...
The TandemRepeats Database (TRDB) is a database of tandemrepeats in genomic DNA. Tandemrepeats Gelfand, Yevgeniy; Rodriguez Alfredo; Benson Gary (January...
when a sequence of repetitive nucleotides (tandemrepeats) are found at the site of replication. Tandemrepeats are unstable regions of the genome where...
that are highly variable, called variable number tandemrepeats (VNTRs), in particular short tandemrepeats (STRs), also known as microsatellites, and minisatellites...
terminating in a tryptophan-aspartic acid (W-D) dipeptide. Tandem copies of these repeats typically fold together to form a type of circular solenoid...
programs exist to perform de novo repeat identification, all operating under the same general principles. As short tandemrepeats are generally 1–6 base pairs...
sequences and structures to find, characterize and annotate protein tandemrepeats. Fournier D, Palidwor GA, Shcherbinin S, Szengel A, Schaefer MH, Perez-Iratxeta...
The tetratricopeptide repeat (TPR) is a structural motif. It consists of a degenerate 34 amino acid tandemrepeat identified in a wide variety of proteins...
of tandemrepeats) DNA. Confusingly, minisatellites are often referred to as VNTRs, and microsatellites are often referred to as short tandemrepeats (STRs)...
typing for M. tuberculosis are noted. The first scheme, called exact tandemrepeat, used only five loci, but the resolution afforded by these five loci...
terminal repeats are in the same direction and inverted terminal repeats are opposite to each other in direction. Tandemrepeats (tandemrepeat sequences)...
includes a variable number tandemrepeat (VNTR) segment (boxes in schematic diagram). In allele c, there are five repeats in the VNTR, and the probe detects...
occurs as a set of five to seven kelch tandemrepeats that form a β-propeller tertiary structure. Kelch-repeat β-propellers are generally involved in...
together with minisatellite and microsatellite DNA, constitute the tandemrepeats. The size of satellite DNA arrays varies greatly between individuals...
in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin tandemrepeats mediate protein–protein interactions and are among the most common structural...
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