Ribbon diagram of the C-terminal WD40 domain of Tup1 (a transcriptional corepressor in yeast), which adopts a 7-bladed beta-propeller fold. Ribbon is colored from blue (N-terminus) to red (C-terminus).[1]
The WD40 repeat (also known as the WD or beta-transducin repeat) is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide.[2] Tandem copies of these repeats typically fold together to form a type of circular solenoid protein domain called the WD40 domain.
^PDB: 1erj; Sprague ER, Redd MJ, Johnson AD, Wolberger C (June 2000). "Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast". EMBO J. 19 (12): 3016–27. doi:10.1093/emboj/19.12.3016. PMC 203344. PMID 10856245.
^Neer EJ, Schmidt CJ, Nambudripad R, Smith TF (September 1994). "The ancient regulatory-protein family of WD-repeat proteins". Nature. 371 (6495): 297–300. Bibcode:1994Natur.371..297N. doi:10.1038/371297a0. PMID 8090199. S2CID 600856.
The WD40repeat (also known as the WD or beta-transducin repeat) is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic...
dictionary. WD40 may refer to: WD-40, widely available water-displacing spray WD-40 Company, the company manufacturing the spray WD40repeat, a structural...
Tandem repeat proteins frequently function as protein-protein interaction modules. The WD40repeat is a prime example of this function. Tandem repeats are...
by three transcription factors: R2R3 MYB, basic helix-loop-helix, and WD40repeat. The three groups of TFs form a trimer complex (MBW) and activate the...
WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40repeat protein interacting with...
of individual repeats is not arbitrary. In the case of WD40repeats (perhaps the largest family of closed solenoids) the number of repeats can range from...
WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene. DCAF11 is a WD40repeat protein, containing seven repeats of the...
(InterPro: IPR004020), the HEAT repeat domain (InterPro: IPR004155), the WD40repeat (InterPro: IPR001680), the leucine-rich repeat (LRR) or the BIR repeat (InterPro: IPR001370)...
sapiens. It has short up and down stream untranslated regions as well as WD40repeat regions which have been linked to various functions (signal transduction...
ld produces a homeodomain and Blazquez et al 2001 that fve produces a WD40repeat. The UVR8 protein detects UV-B light and mediates the response to this...
the F-box domain, which is a conserved dimerization motif located in WD40repeat F box proteins, such as Cdc4, Met30, β-TrCP and Pop1/2. But Vts1, a RNA...
consisting of repeats that can be stacked together as bulk building blocks. There are beta-propeller domain with similarities to WD40repeats, and more interestingly...
methyltransferase complexes containing a protein WDR5, which contains the WD40repeat protein motif. WDR5 associates specifically with dimethylated H3K4 and...
acids, and has a molecular weight of 187.7 kDa. It contains multiple WD40repeat domains and one domain of unknown function. This protein is conserved...
WD40repeat-containing protein SMU1 is a protein that in humans is encoded by the SMU1 gene. GRCh38: Ensembl release 89: ENSG00000122692 – Ensembl, May...
Glutamate-rich WD repeat-containing protein 1 is a WD40repeat protein that in humans is encoded by the GRWD1 gene. It localizes to the nucleus and has...
this gene has sequence similarity with members of the WD40repeat-containing protein family. The WD40 group is a large family of proteins, which appear to...
repeat containing planar cell polarity effector is a protein that in humans is encoded by the WDPCP gene. This gene encodes a cytoplasmic WD40repeat...
that connect the 15 nurse cells to the developing oocyte in Drosophila. WD40repeat Kelch protein Ito N, Phillips SE, Stevens C, et al. (March 1991). "Novel...
domain (NB-ARC), few short helical domains and then several copies of the WD40repeat domain. Upon binding cytochrome c and dATP, this protein forms an oligomeric...
of individual repeats is not arbitrary. In the case of WD40repeats (perhaps the largest family of closed solenoids) the number of repeats can range from...
this gene has sequence similarity with members of the WD40repeat-containing protein family. The WD40 group is a large family of proteins that appear to...
encodes a nuclear protein, which belongs to a highly conserved family of WD40repeat. This gene is present in many protein complexes that are involved in...
a member of the WIPI or SVP1 family of WD40repeat-containing proteins. The protein contains seven WD40repeats that are thought to fold into a beta-propeller...
highly dependent upon its recruitment by the PRC2 complex. In particular, WD40-repeat protein embryonic ectoderm development (EED) and zinc finger protein...
[supplied by OMIM] Along with other nucleoporins. It folds into a canonical WD40repeat domain. High expression of NUP43 in breast cancer is associated with...
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