respiratory gaseous exchange by respiratory system
reactive oxygen species metabolic process
regulation of cytokine production
negative regulation of T cell proliferation
macrophage chemotaxis
defense response to bacterium
regulation of immune response
lung alveolus development
innate immune response
toll-like receptor signaling pathway
induction of bacterial agglutination
regulation of adhesion of symbiont to host epithelial cell
developmental process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6441
20390
Ensembl
ENSG00000133661
ENSMUSG00000021795
UniProt
P35247
P50404
RefSeq (mRNA)
NM_003019
NM_009160
RefSeq (protein)
NP_003010
NP_033186
Location (UCSC)
Chr 10: 79.94 – 79.98 Mb
Chr 14: 40.89 – 40.91 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Surfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of lectins called collectin.[5] In humans, SP-D is encoded by the SFTPD gene[6][7] and is part of the innate immune system.[8][9] Each SP-D subunit is composed of an N-terminal domain, a collagenous region, a nucleating neck region, and a C-terminal lectin domain.[5][10] Three of these subunits assemble to form a homotrimer, which further assemble into a tetrameric complex.[5][10]
^ abcGRCh38: Ensembl release 89: ENSG00000133661 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021795 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcHoppe HJ, Barlow PN, Reid KB (May 1994). "A parallel three stranded alpha-helical bundle at the nucleation site of collagen triple-helix formation". FEBS Letters. 344 (2–3): 191–5. Bibcode:1994FEBSL.344..191H. doi:10.1016/0014-5793(94)00383-1. PMID 8187882. S2CID 2920539.
^Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, et al. (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Archives of Biochemistry and Biophysics. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
^Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". The Biochemical Journal. 284. 284 (3): 795–802. doi:10.1042/bj2840795. PMC 1132609. PMID 1339284.
^"Entrez Gene: SFTPD surfactant, pulmonary-associated protein D".
^Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). "Surfactant protein D alters allergic lung responses in mice and human subjects". The Journal of Allergy and Clinical Immunology. 121 (5): 1140–1147.e2. doi:10.1016/j.jaci.2008.02.011. PMC 4145593. PMID 18355911.
^ abCrouch E, Persson A, Chang D, Heuser J (June 1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". The Journal of Biological Chemistry. 269 (25): 17311–9. doi:10.1016/S0021-9258(17)32556-5. PMID 8006040.
and 27 Related for: Surfactant protein D information
SurfactantproteinD, also known as SP-D, is a lung surfactantprotein part of the collagenous family of lectins called collectin. In humans, SP-D is encoded...
Pulmonary surfactant is a surface-active complex of phospholipids and proteins formed by type II alveolar cells. The proteins and lipids that make up...
molecular biology, Pulmonary surfactantproteinD (SP-D) is a protein domain predominantly found in lung surfactant. This protein plays a special role; its...
Surfactantprotein A is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. It is part of the innate...
Surfactantprotein B is an essential lipid-associated protein found in pulmonary surfactant. Without it, the lung would not be able to inflate after a...
Surfactantprotein C (SP-C), is one of the pulmonary surfactantproteins. In humans this is encoded by the SFTPC gene. It is a membrane protein. SFTPC...
Surfactants are chemical compounds that decrease the surface tension or interfacial tension between two liquids, a liquid and a gas, or a liquid and a...
Working with John Heuser, she examined a surfactantprotein, SP-D, and researched the interactions between SP-D and influenza A virus. She has also used...
Surfactantprotein A1 (SP-A1), also known as Pulmonary surfactant-associated protein A1 (PSP-A) is a protein that in humans is encoded by the SFTPA1 gene...
Surfactantprotein A2 (SP-A2), also known as Pulmonary surfactant-associated protein A2 (PSP-A2) is a protein that in humans is encoded by the SFTPA2...
been linked to dysfunction of surfactant metabolism. Surfactant is a mixture of 90% phospholipids and 10% other proteins, produced by epithelial type II...
and can result from a genetic problem with the production of surfactant-associated proteins. IRDS affects about 1% of newborns and is the leading cause...
A dimer Inovirus (filamentous phage) major coat protein Pilin Pulmonary surfactant-associated protein Monoamine oxidases A and B Fatty acid amide hydrolase...
trigger cytokine production by macrophages following opsonization with surfactantproteinD. Infect. Immun. 73:8282-8290; 2005. Cooks, T., Arazi, L., Efrati...
domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactantproteinD independently of carbohydrate recognition. This indicates that DMBT1...
reduce the surface tension of the alveolar liquid, the proteins and other lipids in the surfactant further facilitate the adsorption of oxygen into the...
S, Derrick M, Poulain F (Nov 1998). "Structure and properties of surfactantprotein B". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease...
the glycolipids of pulmonary surfactant. Impaired surfactant regulation can cause an accumulation of surfactantproteins to build up in the alveoli in...
Amyloids are aggregates of proteins characterised by a fibrillar morphology of typically 7–13 nm in diameter, a β-sheet secondary structure (known as cross-β)...
"casein micelles": aggregates of several thousand protein molecules with superficial resemblance to a surfactant micelle, bonded with the help of nanometer-scale...
metalloproteinase activity, oxidant production and emphysema in surfactantproteinD gene-inactivated mice". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5972–7...
evaporative cooling. Further, it is speculated that the presence of a surfactantprotein in the saliva of ruminant animals (e.g., cow, horse, sheep) may assist...
CH3(CH2)11OSO3Na and structure H3C−(CH2)11−O−S(=O)2−O−Na+. It is an anionic surfactant used in many cleaning and hygiene products. This compound is the sodium...
mechanisms by preventing surfactant from spreading over the alveolar surface, decreasing the concentration of surfactantproteins (SP-A and SP-B), and by...
A detergent is a surfactant or a mixture of surfactants with cleansing properties when in dilute solutions. There are a large variety of detergents, a...
separate the protein, α-lactalbumin, from a whey protein solution. pH is an important factor in foaming because it will determine if a surfactant will be able...
Global Information
