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Surfactant protein A information


surfactant, pulmonary-associated protein A1
Identifiers
SymbolSFTPA1
Alt. symbolsSFTP1
NCBI gene6435
HGNC10798
OMIM178630
RefSeqNM_005411
UniProtQ8IWL2
Other data
LocusChr. 10 q22.3
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StructuresSwiss-model
DomainsInterPro
surfactant, pulmonary-associated protein A2B
Identifiers
SymbolSFTPA2B
NCBI gene6436
HGNC10799
OMIM178642
RefSeqNM_006926
UniProtQ8IWL1
Other data
LocusChr. 10 q22.3
Search for
StructuresSwiss-model
DomainsInterPro

Surfactant protein A is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. It is part of the innate immune system and is used to opsonize bacterial cells in the alveoli marking them for phagocytosis by alveolar macrophages. SP-A may also play a role in negative feedback limiting the secretion of pulmonary surfactant. SP-A is not required for pulmonary surfactant to function but does confer immune effects to the organism.[1]

  1. ^ Boron W, Boulpaep E (2012). Medical Physiology (2nd ed.). Philadelphia: Elsevier.

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Surfactant protein A

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Surfactant protein A is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. It is part of the innate...

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Pulmonary surfactant

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Pulmonary surfactant is a surface-active complex of phospholipids and proteins formed by type II alveolar cells. The proteins and lipids that make up...

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Surfactant protein B

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Surfactant protein B is an essential lipid-associated protein found in pulmonary surfactant. Without it, the lung would not be able to inflate after a...

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Surfactant protein C

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Surfactant protein C (SP-C), is one of the pulmonary surfactant proteins. In humans this is encoded by the SFTPC gene. It is a membrane protein. SFTPC...

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Surfactant protein D

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Surfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of lectins called collectin. In humans, SP-D is encoded...

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Surfactant protein A1

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Surfactant protein A1 (SP-A1), also known as Pulmonary surfactant-associated protein A1 (PSP-A) is a protein that in humans is encoded by the SFTPA1 gene...

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Surfactant

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Surfactants are chemical compounds that decrease the surface tension or interfacial tension between two liquids, a liquid and a gas, or a liquid and a...

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Surfactant protein A2

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Surfactant protein A2 (SP-A2), also known as Pulmonary surfactant-associated protein A2 (PSP-A2) is a protein that in humans is encoded by the SFTPA2...

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Collectin

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mannan-binding lectin (mannose-binding lectin) SP-A = surfactant protein A SP-D = surfactant protein D CL-L1 = collectin liver 1 CL-P1 = collectin placenta...

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Surfactant metabolism dysfunction

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been linked to dysfunction of surfactant metabolism. Surfactant is a mixture of 90% phospholipids and 10% other proteins, produced by epithelial type II...

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Pulmonary surfactant protein D

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molecular biology, Pulmonary surfactant protein D (SP-D) is a protein domain predominantly found in lung surfactant. This protein plays a special role; its primary...

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Pulmonary alveolus

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surfactant regulation can cause an accumulation of surfactant proteins to build up in the alveoli in a condition called pulmonary alveolar proteinosis....

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Opsonin

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PC. Collectin molecules such as mannose-binding lectin (MBL), surfactant protein A (SP-A), and SP-D interact with unknown ligands on apoptotic cell membranes...

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Dipalmitoylphosphatidylcholine

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liquid, the proteins and other lipids in the surfactant further facilitate the adsorption of oxygen into the air-liquid interface. DPPC is a variant of...

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Infant respiratory distress syndrome

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and can result from a genetic problem with the production of surfactant-associated proteins. IRDS affects about 1% of newborns and is the leading cause...

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Erika Crouch

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with John Heuser, she examined a surfactant protein, SP-D, and researched the interactions between SP-D and influenza A virus. She has also used structure-function...

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Interstitial lung disease

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lung biopsy. Testing is available for Surfactant protein B deficiency (mutations in SFTPB) Surfactant protein C deficiency (mutations in SFTPC) ABCA3...

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Meconium aspiration syndrome

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mechanisms by preventing surfactant from spreading over the alveolar surface, decreasing the concentration of surfactant proteins (SP-A and SP-B), and by changing...

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Ambroxol

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Wichert P, Fehrenbach H (February 2005). "Cell-specific modulation of surfactant proteins by ambroxol treatment". Toxicology and Applied Pharmacology. 203...

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Beractant

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is a modified bovine pulmonary surfactant containing bovine lung extract (phospholipids, neutral lipids, fatty acids, and bovine surfactant proteins),...

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Cleavable detergent

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cleavable surfactants, are special surfactants (detergents) that are used in biochemistry and especially in proteomics to enhance protein denaturation...

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Zymosan

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down-regulated by lung collectin surfactant protein A". J. Immunol. 171 (1): 417–25. doi:10.4049/jimmunol.171.1.417. PMID 12817025. Zymosan A from Saccharomyces cerevisiae...

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DMBT1

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has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor...

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BPIFA4P

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sweat, acting as a wetting agent to facilitate evaporative cooling. Further, it is speculated that the presence of a surfactant protein in the saliva of...

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Proteinopathy

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([pref. protein]; -pathy [suff. disease]; proteinopathies pl.; proteinopathic adj), or proteopathy, protein conformational disorder, or protein misfolding...

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NK2 homeobox 1

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CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1)". The Journal...

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Peptoid

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candidates for a range of different biomedical applications, including antimicrobial agents, synthetic lung surfactants, ligands for various proteins including...

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