Surfactant protein A is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. It is part of the innate immune system and is used to opsonize bacterial cells in the alveoli marking them for phagocytosis by alveolar macrophages. SP-A may also play a role in negative feedback limiting the secretion of pulmonary surfactant. SP-A is not required for pulmonary surfactant to function but does confer immune effects to the organism.[1]
^Boron W, Boulpaep E (2012). Medical Physiology (2nd ed.). Philadelphia: Elsevier.
and 27 Related for: Surfactant protein A information
SurfactantproteinA is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. It is part of the innate...
Pulmonary surfactant is a surface-active complex of phospholipids and proteins formed by type II alveolar cells. The proteins and lipids that make up...
Surfactantprotein B is an essential lipid-associated protein found in pulmonary surfactant. Without it, the lung would not be able to inflate after a...
Surfactantprotein C (SP-C), is one of the pulmonary surfactantproteins. In humans this is encoded by the SFTPC gene. It is a membrane protein. SFTPC...
Surfactantprotein D, also known as SP-D, is a lung surfactantprotein part of the collagenous family of lectins called collectin. In humans, SP-D is encoded...
Surfactantprotein A1 (SP-A1), also known as Pulmonary surfactant-associated protein A1 (PSP-A) is aprotein that in humans is encoded by the SFTPA1 gene...
Surfactants are chemical compounds that decrease the surface tension or interfacial tension between two liquids, a liquid and a gas, or a liquid and a...
been linked to dysfunction of surfactant metabolism. Surfactant is a mixture of 90% phospholipids and 10% other proteins, produced by epithelial type II...
molecular biology, Pulmonary surfactantprotein D (SP-D) is aprotein domain predominantly found in lung surfactant. This protein plays a special role; its primary...
surfactant regulation can cause an accumulation of surfactantproteins to build up in the alveoli in a condition called pulmonary alveolar proteinosis....
PC. Collectin molecules such as mannose-binding lectin (MBL), surfactantproteinA (SP-A), and SP-D interact with unknown ligands on apoptotic cell membranes...
liquid, the proteins and other lipids in the surfactant further facilitate the adsorption of oxygen into the air-liquid interface. DPPC is a variant of...
and can result from a genetic problem with the production of surfactant-associated proteins. IRDS affects about 1% of newborns and is the leading cause...
with John Heuser, she examined asurfactantprotein, SP-D, and researched the interactions between SP-D and influenza A virus. She has also used structure-function...
mechanisms by preventing surfactant from spreading over the alveolar surface, decreasing the concentration of surfactantproteins (SP-A and SP-B), and by changing...
Wichert P, Fehrenbach H (February 2005). "Cell-specific modulation of surfactantproteins by ambroxol treatment". Toxicology and Applied Pharmacology. 203...
cleavable surfactants, are special surfactants (detergents) that are used in biochemistry and especially in proteomics to enhance protein denaturation...
down-regulated by lung collectin surfactantproteinA". J. Immunol. 171 (1): 417–25. doi:10.4049/jimmunol.171.1.417. PMID 12817025. Zymosan A from Saccharomyces cerevisiae...
has been shown to bind surfactantprotein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor...
sweat, acting as a wetting agent to facilitate evaporative cooling. Further, it is speculated that the presence of asurfactantprotein in the saliva of...
([pref. protein]; -pathy [suff. disease]; proteinopathies pl.; proteinopathic adj), or proteopathy, protein conformational disorder, or protein misfolding...
CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactantprotein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1)". The Journal...
candidates for a range of different biomedical applications, including antimicrobial agents, synthetic lung surfactants, ligands for various proteins including...