X-ray showing the extent of lung epithelial damage in response to meconium seen in neonates with meconium aspiration syndrome.
Specialty
Neonatology
Meconium aspiration syndrome (MAS) also known as neonatal aspiration of meconium is a medical condition affecting newborn infants. It describes the spectrum of disorders and pathophysiology of newborns born in meconium-stained amniotic fluid (MSAF) and have meconium within their lungs. Therefore, MAS has a wide range of severity depending on what conditions and complications develop after parturition. Furthermore, the pathophysiology of MAS is multifactorial and extremely complex which is why it is the leading cause of morbidity and mortality in term infants.[1][2]
The word meconium is derived from the Greek word mēkōnion meaning juice from the opium poppy as the sedative effects it had on the foetus were observed by Aristotle.[3]
Meconium is a sticky dark-green substance which contains gastrointestinal secretions, amniotic fluid, bile acids, bile, blood, mucus, cholesterol, pancreatic secretions, lanugo, vernix caseosa and cellular debris.[1] Meconium accumulates in the foetal gastrointestinal tract throughout the third trimester of pregnancy and it is the first intestinal discharge released within the first 48 hours after birth.[4] Notably, since meconium and the whole content of the gastrointestinal tract is located 'extracorporeally,' its constituents are hidden and normally not recognised by the foetal immune system.[5]
For the meconium within the amniotic fluid to successfully cause MAS, it has to enter the respiratory system during the period when the fluid-filled lungs transition into an air-filled organ capable of gas exchange.[1]
^ abcVan Ierland, Y; De Beaufort, AJ (2009). "Why Does Meconium Cause Meconium Aspiration Syndrome? Current Concepts of MAS Pathophysiology". Early Human Development. 85 (10): 617–620. doi:10.1016/j.earlhumdev.2009.09.009. PMID 19833459.
^Vain, NE; Batton, DG (2017). "Meconium "Aspiration" (or Respiratory Distress Associated with Meconium-Stained Amniotic Fluid?)". Seminars in Foetal and Neonatal Medicine. 22 (4): 214–219. doi:10.1016/j.siny.2017.04.002. PMID 28411000.
^Rahman, S; Unsworth, J; Vause, S (2013). "Meconium in Labour". Obstetrics, Gynaecology and Reproductive Medicine. 23 (8): 247–252. doi:10.1016/j.ogrm.2013.05.007.
^Argyridis, S; Arulkumaran, S (2016). "Meconium Stained Amniotic Fluid". Obstetrics, Gynaecology and Reproductive Medicine. 26 (8): 227–230. doi:10.1016/j.ogrm.2016.05.001.
^Lindenskov, PHH; Castellheim, A; Saugstad, OD (2015). "Meconium Aspiration Syndrome: Possible Pathophysiological Mechanisms and Future Potential Therapies". Neonatology. 107 (3): 225–230. doi:10.1159/000369373. PMID 25721501.
and 25 Related for: Meconium aspiration syndrome information
Meconiumaspirationsyndrome (MAS) also known as neonatal aspiration of meconium is a medical condition affecting newborn infants. It describes the spectrum...
asthma and exercise intolerance. MeconiumAspirationSyndrome occurs in full term or post-term infants who aspirate meconium. Risk factors include a diabetic...
preventing adequate breathing. The presence of meconium within the lungs, known as meconiumaspirationsyndrome, can obstruct the airways and also deactivate...
both the mother and the baby, including fetal malnutrition, meconiumaspirationsyndrome, and stillbirths. After the 42nd week of gestation, the placenta...
cord compression. It has also been used to reduce the risk of meconiumaspirationsyndrome, though evidence of benefit is mixed. The UK National Institute...
distress syndrome (IRDS), also known as surfactant deficiency disorder (SDD), and previously called hyaline membrane disease (HMD), is a syndrome in premature...
selection, a genome-tagging technique Meconiumaspirationsyndrome, neonatal aspiration of meconium McCune–Albright syndrome, a genetic disorder which results...
births carry risks for both the mother and the baby, including meconiumaspirationsyndrome, fetal malnutrition, and stillbirths. The placenta, which supplies...
distress syndrome because the evidence regarding its effect on patient-important outcomes is inconsistent. Respiratory care Nursing Neonatology Meconium aspiration...
Biomarkers being studied include fatty acid ethyl esters (FAEE) detected in the meconium (first feces of an infant) and hair. FAEE may be present if chronic alcohol...
literature data suggest a radical change in the treatment of meconiumaspirationsyndrome (MAS) by considering the use of a liquid ventilator. The demonstration...
Fairman. After Nevaeh's birth, it is discovered that she may have meconiumaspirationsyndrome, but after a short hospital stay, the baby is healthy enough...
to a colt that died two days later due to complications from meconiumaspirationsyndrome. Zenyatta was bred to Medaglia d'Oro in 2016 and delivered a...
mouth and throat of infants with meconium-stained amniotic fluid has not been found to reduce the rate of aspiration pneumonia and may cause potential...
Global Information