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Ambroxol information


Ambroxol
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
oral, inhaled, intramuscular, intravenous
ATC code
  • R05CB06 (WHO) R02AD05 (WHO)
Legal status
Legal status
  • In general: Over-the-counter (OTC)
Identifiers
IUPAC name
  • trans-4-(2-Amino-3,5-dibromobenzylamino)-cyclohexanol
CAS Number
  • 18683-91-5 ☒N
PubChem CID
  • 2132
ChemSpider
  • 10276826 checkY
UNII
  • 200168S0CL
KEGG
  • D07442 checkY
ChEMBL
  • ChEMBL153479 checkY
CompTox Dashboard (EPA)
  • DTXSID8022583 Edit this at Wikidata
ECHA InfoCard100.038.621 Edit this at Wikidata
Chemical and physical data
FormulaC13H18Br2N2O
Molar mass378.108 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O[C@H]2CC[C@H](NCc1cc(Br)cc(Br)c1N)CC2
InChI
  • InChI=1S/C13H18Br2N2O/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10/h5-6,10-11,17-18H,1-4,7,16H2/t10-,11- checkY
  • Key:JBDGDEWWOUBZPM-XYPYZODXSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ambroxol is a drug that breaks up phlegm, used in the treatment of respiratory diseases associated with viscid or excessive mucus. Ambroxol is often administered as an active ingredient in cough syrup.

It was patented in 1966 and came into medical use in 1979.[1]

  1. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 544. ISBN 9783527607495.

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Ambroxol

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Ambroxol is a drug that breaks up phlegm, used in the treatment of respiratory diseases associated with viscid or excessive mucus. Ambroxol is often administered...

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Lysosome

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amitriptyline. Ambroxol is a lysosomotropic drug of clinical use to treat conditions of productive cough for its mucolytic action. Ambroxol triggers the...

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Lysosomal storage disease

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experimental technique of gene therapy may offer cures in the future. Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase...

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Mucoactive agent

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Holland, & Bostwick, 2008, p. 591 Mucoactive drugs include: acetylcysteine ambroxol ammonium chloride bromhexine carbocisteine dornase alfa erdosteine guaifenesin...

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Cold medicine

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the airways, lungs, bronchi, and trachea. Examples are carbocisteine, ambroxol, and bromhexine. Expectorants are substances claimed to make coughing easier...

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Neuropathic pain

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severe cases of ongoing neuropathic pain it is delivered intrathecally. Ambroxol is a drug that reduces mucus. Preclinical research suggests it may produce...

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Bromhexine

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Pharmacokinetic data Bioavailability 75–80% Metabolism Extensive hepatic Metabolites Ambroxol, others Elimination half-life 12 hr Excretion Urine Identifiers IUPAC name...

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Azithromycin

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nimesulide as Zitroflam; in a combination with tinidazole and fluconazole as Trivafluc, and in a combination with ambroxol as Zathrin-AX, Laz-AX and Azro-AM....

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Loratadine

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combination drug formulations with pseudoephedrine, paracetamol, betamethasone, ambroxol, salbutamol, phenylephrine, and dexamethasone. The marketing of the Claritin...

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Rifampicin

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be potentiated by isoniazid (through inhibiting mycolate synthesis) and ambroxol (through host directed effects in autophagy and pharmacokinetics). Rifampicin...

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Calcium channel opener

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calcium channels. In contrast to Bay K8644, which is not for clinical use, ambroxol is a frequently used mucolytic drug that triggers lysosomal secretion by...

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ATC code R02

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Benzocaine R02AD02 Lidocaine R02AD03 Cocaine R02AD04 Dyclonine R02AD05 Ambroxol R02AX01 Flurbiprofen R02AX02 Ibuprofen R02AX03 Benzydamine "ATC (Anatomical...

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Boehringer Ingelheim

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injection are manufactured by GlaxoSmithKline Mucoangin / Mucosolvan (ambroxol) Pharmaton (standardized ginseng extract, vitamins, minerals, trace elements)...

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ATC code R05

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Bromhexine R05CB03 Carbocisteine R05CB04 Eprazinone R05CB05 Mesna R05CB06 Ambroxol R05CB07 Sobrerol R05CB08 Domiodol R05CB09 Letosteine R05CB10 Combinations...

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Erdosteine

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to other muco-regulatory drugs (such as N-acetylcysteina, sobrerol and ambroxol). Chronic Obstructive Pulmonary Disease Evidence obtained in patients with...

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ATC code R03

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R03CC15 Formoterol R03CC53 Terbutaline, combinations R03CC63 Clenbuterol and ambroxol QR03CC90 Clenbuterol, combinations R03DA01 Diprophylline R03DA02 Choline...

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Dementia with Lewy bodies

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aim to reduce brain levels of alpha-synuclein (with the pharmaceuticals ambroxol, NPT200-11, and E2027), or to use immunotherapy to reduce widespread neuroinflammation...

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Van Andel Institute

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disease-modifying treatments for Parkinson's. LCT has supported trials in ambroxol, exenatide, simvastatin, liraglutide, and others. In October, the institute...

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Vojo Deretic

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reduced cytopathic effects, quantitative RT-PCR and plaque forming units. Ambroxol is another drug that has beneficial effects in Vero E6 cells. A comprehensive...

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List of compounds with carbon number 13

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C13H17NO3 lophophorine 17627-78-0 C13H17N3O aminopyrine 58-15-1 C13H18Br2N2O ambroxol 18683-91-5 C13H18ClNO Bupropion 34911-55-2 C13H18ClNO monalide 7287-36-7...

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