This article is about serotonin reuptake inhibitors. For SSRIs, see selective serotonin reuptake inhibitor.
A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT). This in turn leads to increased extracellular concentrations of serotonin and, therefore, an increase in serotonergic neurotransmission. It is a type of monoamine reuptake inhibitor (MRI); other types of MRIs include dopamine reuptake inhibitors and norepinephrine reuptake inhibitors.
SRIs are not synonymous with selective serotonin reuptake inhibitors (SSRIs), as the latter term is usually used to describe the class of antidepressants of the same name, and because SRIs, unlike SSRIs, can either be selective or non-selective in their action. For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI.
SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs, and TCAs), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders. Less often, SRIs are also used to treat a variety of other medical conditions including neuropathic pain and fibromyalgia (e.g., duloxetine, milnacipran), and premature ejaculation (e.g., dapoxetine) as well as for dieting (e.g., sibutramine). Additionally, some clinically used drugs such as chlorpheniramine, dextromethorphan, and methadone possess SRI properties secondarily to their primary mechanism of action(s) and this contributes to their side effect and drug interaction profiles.
A closely related type of drug is a serotonin releasing agent (SRA), an example of which is fenfluramine.
and 26 Related for: Serotonin reuptake inhibitor information
Selective serotoninreuptakeinhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder...
A serotoninreuptakeinhibitor (SRI) is a type of drug which acts as a reuptakeinhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT)...
Serotonin antagonist and reuptakeinhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act...
reuptakeinhibitor (NRI, NERI) or noradrenaline reuptakeinhibitor or adrenergic reuptakeinhibitor (ARI), is a type of drug that acts as a reuptake inhibitor...
A dopamine reuptakeinhibitor (DRI) is a class of drug which acts as a reuptakeinhibitor of the monoamine neurotransmitter dopamine by blocking the action...
monoamine reuptakeinhibitor (MRI) is a drug that acts as a reuptakeinhibitor of one or more of the three major monoamine neurotransmitters serotonin, norepinephrine...
serotonin neurotransmitter system. To be precise, SMSs simultaneously modulate one or more serotonin receptors and inhibit the reuptake of serotonin....
serotoninreuptakeinhibitors (SSRIs) and serotonin–norepinephrine reuptakeinhibitors (SNRIs), interfere with the normal reabsorption of serotonin after...
of serotonin to transporters (serotoninreuptakeinhibitors, or SRIs) are used to treat mental disorders. The selective serotoninreuptakeinhibitor (SSRI)...
A GABA reuptakeinhibitor (GRI) is a type of drug which acts as a reuptakeinhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking...
name Zoloft among others, is an antidepressant of the selective serotoninreuptakeinhibitor (SSRI) class. The effectiveness of sertraline for depression...
prescribed an SSRI in early pregnancy. Vilazodone acts as a serotoninreuptakeinhibitor (IC50 = 2.1 nM; Ki = 0.1 nM) and 5-HT1A receptor partial agonist...
Prozac, among others, is an antidepressant of the selective serotoninreuptakeinhibitor (SSRI) class. It is used for the treatment of major depressive...
(trade names Ixel, Savella, Dalcipran, Toledomin) is a serotonin–norepinephrine reuptakeinhibitor (SNRI) used in the clinical treatment of fibromyalgia...
name Luvox among others, is an antidepressant of the selective serotoninreuptakeinhibitor (SSRI) class. It is primarily used to treat major depressive...
Mirtazapine in combination with a selective serotoninreuptakeinhibitor, serotonin–norepinephrine reuptakeinhibitor, or tricyclic antidepressant as an augmentation...
name Celexa among others, is an antidepressant of the selective serotoninreuptakeinhibitor (SSRI) class. It is used to treat major depressive disorder,...
to treat depression. It is an antidepressant of the serotonin-norepinephrine reuptakeinhibitor (SNRI) class and is taken by mouth. It is recommended...
class of serotonin modulators and stimulators, which also includes vilazodone. More specifically, vortioxetine is a serotoninreuptakeinhibitor, agonist...
relative to the selective serotoninreuptakeinhibitors (SSRIs). A closely related type of drug is a serotoninreuptakeinhibitor (SRI). Amphetamines like...