Drug that makes neurotransmitter transporters more active
Coluracetam, a high-affinity choline uptake (HACU) enhancer
A reuptake enhancer (RE), also sometimes referred to as a reuptake activator, is a type of reuptake modulator which enhances the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to a decrease in the extracellular concentrations of the neurotransmitter and therefore a decrease in neurotransmission.
The antidepressant tianeptine was once claimed to be a (selective) serotonin reuptake enhancer (SRE or SSRE), but the role of serotonin reuptake in its mechanism is doubtful. Tianeptine has no affinity for the serotonin transporter, neither increases nor decreases extracellular levels of serotonin in cortico-limbic structures of conscious rats, and it didn't show any other long-term effect on the serotonin pathway.[1] Ultimately, tianeptine was determined to be a selective mu opioid receptor agonist.
Coluracetam is a choline-reuptake enhancer.[2] The flavone luteoline as well as some of its derivatives enhance the reuptake at the dopamine transporter,[3][4] extracts of Caulis Sinomenii activate DA/NE transporters.[5]
^McEwen, B. S.; Chattarji, S.; Diamond, D. M.; Jay, T. M.; Reagan, L. P.; Svenningsson, P.; Fuchs, E. (March 2010). "The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation". Molecular Psychiatry. 15 (3): 237–249. doi:10.1038/mp.2009.80. PMC 2902200. PMID 19704408.
^Zhao G, Qin GW, Wang J, Chu WJ, Guo LH (2010). "Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt". Neurochem. Int. 56 (1): 168–76. doi:10.1016/j.neuint.2009.09.015. PMID 19815045. S2CID 24753206.
^Zhang J, Liu X, Lei X, et al. (2010). "Discovery and synthesis of novel luteolin derivatives as DAT agonists". Bioorg. Med. Chem. 18 (22): 7842–8. doi:10.1016/j.bmc.2010.09.049. PMID 20971650.
A reuptakeenhancer (RE), also sometimes referred to as a reuptake activator, is a type of reuptake modulator which enhances the plasmalemmal transporter-mediated...
preclinical studies. Tianeptine is no longer labelled a selective serotonin reuptakeenhancer (SSRE) antidepressant. Tianeptine had been found to bind to the same...
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic...
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reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor...
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element which regulates splicing acting in cis Serotonin reuptakeenhancer, a type of reuptakeenhancer Serum response element, a DNA cis-regulatory element...
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degradation – proteins called enzymes break the neurotransmitters down. Reuptake – neurotransmitters are reabsorbed into the pre-synaptic neuron. Transporters...
disorders. Onset of action appears faster than some selective serotonin reuptake inhibitors and similar to tricyclic antidepressants. In 2010, the National...
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