Protein-coding gene in the species Homo sapiens
SLC41A1 Identifiers Aliases SLC41A1 , MgtE, solute carrier family 41 member 1, NPHPL2External IDs OMIM: 610801; MGI: 2444823; HomoloGene: 14871; GeneCards: SLC41A1; OMA:SLC41A1 - orthologs Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,789,094 bp[1] End 205,813,748 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 131,755,231 bp[2] End 131,776,603 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle cardiac muscle tissue of right atrium apex of heart right ventricle right auricle tibialis anterior muscle body of tongue body of pancreas vena cava Skeletal muscle tissue of biceps brachii
Top expressed in extraocular muscle digastric muscle saccule stria vascularis optic nerve soleus muscle thoracic diaphragm sternocleidomastoid muscle ciliary body plantaris muscle
More reference expression data
BioGPS
Gene ontology Molecular function
cation transmembrane transporter activity
magnesium ion transmembrane transporter activity
magnesium:sodium antiporter activity
transmembrane transporter activity
Cellular component
integral component of membrane
membrane
plasma membrane
basolateral plasma membrane
protein-containing complex
Biological process
cation transport
ion transport
sodium ion transmembrane transport
magnesium ion transmembrane transport
cellular magnesium ion homeostasis
magnesium ion transport
cellular response to magnesium ion
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 1: 205.79 – 205.81 Mb Chr 1: 131.76 – 131.78 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
SLC41A1 is a protein that in humans is encoded by the gene SLC41A1.[5] It is homologous to the prokaryotic Mg++ transfer protein MgtE[6]
Mutations in this gene have been associated to Nephronophthisis-like phenotypes.[7]
^ a b c GRCh38: Ensembl release 89: ENSG00000133065 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013275 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Wabakken T, Rian E, Kveine M, Aasheim HC (July 2003). "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters". Biochemical and Biophysical Research Communications . 306 (3): 718–24. doi:10.1016/S0006-291X(03)01030-1. PMID 12810078.
^ Goytain A, Quamme GA (May 2005). "Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters". Physiological Genomics . 21 (3): 337–42. doi:10.1152/physiolgenomics.00261.2004. PMID 15713785.
^ Hurd TW, Otto EA, Mishima E, Gee HY, Inoue H, Inazu M, et al. (May 2013). "Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype". Journal of the American Society of Nephrology . 24 (6): 967–77. doi:10.1681/ASN.2012101034. PMC 3665398 . PMID 23661805.
Last Update: 2023-03-03T19:54:29Z
SLC41A1 is a protein that in humans is encoded by the gene SLC41A1 . It is homologous to the prokaryotic Mg++ transfer protein MgtE Mutations in this gene...
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Last Update: 2020-09-11T15:10:29Z
for a Synechocystis homologue, and 513 residues for the human homologue, SLC41A1 . These proteins are capable of transporting Mg2+ and Co2+ but not Ni2+...
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Last Update: 2024-05-29T05:19:15Z
(41): Magnesium transporter E SLC41A1 SLC41A2 SLC41A3 (42): Ammonia transporter RhAG RhBG RhCG (43): Na+-independent, system-L like amino-acid transporter...
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