Cytoplasmic view of the binding pocket of ATP–ADP translocase 1, PDB: 1OKC.
Identifiers
Symbol
Aden_trnslctor
Pfam
PF00153
InterPro
IPR002113
TCDB
2.A.29.1.2
OPM superfamily
21
OPM protein
2c3e
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
Identifiers
Symbol
SLC25A4
Alt. symbols
PEO3, PEO2, ANT1
NCBI gene
291
HGNC
10990
OMIM
103220
RefSeq
NM_001151
UniProt
P12235
Other data
Locus
Chr. 4 q35
Search for
Structures
Swiss-model
Domains
InterPro
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
Identifiers
Symbol
SLC25A5
Alt. symbols
ANT2
NCBI gene
292
HGNC
10991
OMIM
300150
RefSeq
NM_001152
UniProt
P05141
Other data
Locus
Chr. X q24-q26
Search for
Structures
Swiss-model
Domains
InterPro
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Identifiers
Symbol
SLC25A6
Alt. symbols
ANT3
NCBI gene
293
HGNC
10992
OMIM
403000
RefSeq
NM_001636
UniProt
P12236
Other data
Locus
Chr. Y p
Search for
Structures
Swiss-model
Domains
InterPro
Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane.[1][2] ANT is the most abundant protein in the inner mitochondrial membrane and belongs to mitochondrial carrier family.[3]
Free ADP is transported from the cytoplasm to the mitochondrial matrix, while ATP produced from oxidative phosphorylation is transported from the mitochondrial matrix to the cytoplasm, thus providing the cells with its main energy currency.[4] ADP/ATP translocases are exclusive to eukaryotes and are thought to have evolved during eukaryogenesis.[5] Human cells express four ADP/ATP translocases: SLC25A4, SLC25A5, SLC25A6 and SLC25A31, which constitute more than 10% of the protein in the inner mitochondrial membrane.[6] These proteins are classified under the mitochondrial carrier superfamily.
^Klingenberg M (October 2008). "The ADP and ATP transport in mitochondria and its carrier". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778 (10): 1978–2021. doi:10.1016/j.bbamem.2008.04.011. PMID 18510943.
^Kunji ER, Aleksandrova A, King MS, Majd H, Ashton VL, Cerson E, Springett R, Kibalchenko M, Tavoulari S, Crichton PG, Ruprecht JJ (October 2016). "The transport mechanism of the mitochondrial ADP/ATP carrier". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. Channels and transporters in cell metabolism. 1863 (10): 2379–93. doi:10.1016/j.bbamcr.2016.03.015. PMID 27001633.
^Palmieri F, Monné M (October 2016). "Discoveries, metabolic roles and diseases of mitochondrial carriers: A review". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. Channels and transporters in cell metabolism. 1863 (10): 2362–78. doi:10.1016/j.bbamcr.2016.03.007. hdl:11563/126168. PMID 26968366.
^Stryer L, Berg JM, Tymoczko JL (2007). Biochemistry. San Francisco: W.H. Freeman. p. 553. ISBN 978-0-7167-8724-2.
^Radzvilavicius AL, Blackstone NW (October 2015). "Conflict and cooperation in eukaryogenesis: implications for the timing of endosymbiosis and the evolution of sex". Journal of the Royal Society, Interface. 12 (111): 20150584. doi:10.1098/rsif.2015.0584. PMC 4614496. PMID 26468067.
^Brandolin G, Dupont Y, Vignais PV (April 1985). "Substrate-induced modifications of the intrinsic fluorescence of the isolated adenine nucleotide carrier protein: demonstration of distinct conformational states". Biochemistry. 24 (8): 1991–7. doi:10.1021/bi00329a029. PMID 2990548.
and 16 Related for: Adenine nucleotide translocator information
Adeninenucleotidetranslocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges...
olefination and Suzuki coupling along with a higher yield by 6.4%. Adeninenucleotidetranslocator, abbreviated as ANT, provides ATP from mitochondria to the...
medical complication AAC, a codon for the amino acid asparagine Adeninenucleotidetranslocator (ANT), also known as the ADP/ATP carrier protein (AAC) This...
where it binds to the adeninenucleotidetranslocator. It does not affect the adeninenucleotide exchange activity of the translocator, but it does lead to...
assembly of adeninenucleotidetranslocator. The SLC25A4 gene encodes the heart and muscle-specific isoform 1 of the mitochondrial adeninenucleotide translocator...
MC, Xie Z, Matsuyama S, Reed JC, Kroemer G (1998). "Bax and adeninenucleotidetranslocator cooperate in the mitochondrial control of apoptosis". Science...
VGLUT as one of the targets for treatment. Active transport Adeninenucleotidetranslocator Cotransporter Reduced folate carrier family Sodium-calcium...
voltage-dependent anion channel (VDAC), the inner membrane protein adeninenucleotidetranslocator (AdNT) and the matrix protein cyclophilin D (CyD) (12). This...
no effect. Bcl-rambo mediates apoptosis by associating with adeninenucleotidetranslocator (ANT), a component of the mitochondrial permeability transition...
in the mitochondrial permeability transition pore component adeninenucleotidetranslocator (ANT). Overexpression of TXN2 was shown to have attenuated...
2001). "Control of mitochondrial membrane permeabilization by adeninenucleotidetranslocator interacting with HIV-1 viral protein rR and Bcl-2". The Journal...
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