positive regulation of transcription by RNA polymerase II
cellular iron ion homeostasis
regulation of transcription from RNA polymerase II promoter in response to iron
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
30061
53945
Ensembl
ENSG00000138449
ENSMUSG00000025993
UniProt
Q9NP59
Q9JHI9
RefSeq (mRNA)
NM_014585
NM_016917
RefSeq (protein)
NP_055400
NP_058613
Location (UCSC)
Chr 2: 189.56 – 189.58 Mb
Chr 1: 45.95 – 45.97 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene.[5] Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell. Ferroportin is the only known iron exporter.[6]
After dietary iron is absorbed into the cells of the small intestine, ferroportin allows that iron to be transported out of those cells and into the bloodstream. Fpn also mediates the efflux of iron recycled from macrophages resident in the spleen and liver.[7]
Ferroportin is regulated by hepcidin, a hormone produced by the liver; hepcidin binds to Fpn and limits its iron-efflux activity, thereby reducing iron delivery to the blood plasma.[8] Therefore, the interaction between Fpn and hepcidin controls systemic iron homeostasis.
^ abcGRCh38: Ensembl release 89: ENSG00000138449 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025993 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, et al. (February 2000). "Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter". Nature. 403 (6771): 776–781. Bibcode:2000Natur.403..776D. doi:10.1038/35001596. PMID 10693807. S2CID 4429026.
^Ward DM, Kaplan J (September 2012). "Ferroportin-mediated iron transport: expression and regulation". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823 (9): 1426–1433. doi:10.1016/j.bbamcr.2012.03.004. PMC 3718258. PMID 22440327.
^Canonne-Hergaux F, Donovan A, Delaby C, Wang HJ, Gros P (January 2006). "Comparative studies of duodenal and macrophage ferroportin proteins". American Journal of Physiology. Gastrointestinal and Liver Physiology. 290 (1): G156–G163. doi:10.1152/ajpgi.00227.2005. PMID 16081760.
^Cite error: The named reference pmid15514116 was invoked but never defined (see the help page).
Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded...
Hemochromatosis type 4 is a hereditary iron overload disorder that affects ferroportin, an iron transport protein needed to export iron from cells into circulation...
low such as in hemochromatosis, iron overload occurs due to increased ferroportin mediated iron efflux from storage and increased gut iron absorption....
mammals, ferroportin. Hephaestin, a ferroxidase that can oxidize Fe2+ to Fe3+ and is found mainly in the small intestine, helps ferroportin transfer iron...
the iron regulatory proteins hemojuvelin, transferrin receptor-2 and ferroportin. Hereditary hemochromatosis is characterized by an accelerated rate of...
African people carry a unique ferroportin mutation that predisposes them iron overload, making it a kind of ferroportin disease. African-Americans, who...
concentrations in excess of 5 μg Mn/m3 can lead to Mn-induced symptoms. Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated...
mammals, ferroportin. Hephaestin, a ferroxidase that can oxidize Fe2+ to Fe3+ and is found mainly in the small intestine, helps ferroportin transfer iron...
and release from the liver. Hepcidin production and release shuts down ferroportin, a protein that controls export of iron from the gut and from iron storing...
for ferroportin, prove the rule: these people have plenty of hepcidin, but their cells lack the proper response to it. So, in people with ferroportin proteins...
the enterocyte to Fe2+ ferroportin allows the passage of iron through the cell membrane for export. In the blood, ferroportin is then converted to transferrin...
stored internally in ferritin or is released into the circulation via ferroportin. In cases where systemic iron levels are raised, or where inflammation...
alleged criminal offence Federated portal network, a software architecture Ferroportin, a protein Filtered-popping network in computer science Fixed-pattern...
raising questions about efficacy of this form of treatment. Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated...
investigators to the discovery of a gene polymorphism in the gene for ferroportin, which predisposes some people of African descent to iron overload. Secondary...
efflux most likely in cooperation with the basolateral iron transporter, ferroportin 1. To a lesser extent hephaestin has been detected in colon, spleen,...
Meta-Analysis". ASN-Online. 2020-10-22. Retrieved 2022-05-20. "Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia"...
hepcidin, ERFE increases the function of the cellular iron export channel, ferroportin. This then results in increased iron absorption from the intestine and...
encode iron metabolism genes, including ferritin, transferrin receptor 1, ferroportin, HIF2 alpha, and several other transcripts. IRP1 acquires an iron-sulfur...
(February 2004). "The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)". Pflügers Archiv. 447 (5): 801–806. doi:10.1007/s00424-003-1102-3...
raising questions about efficacy of this form of treatment. Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated...
Global Information
