Glu_transpt_1IPR002439erythrocyte/brain hexose facilitatorGLUT1glucose transporter-1Gtr1Glut1Glut-1Glucose Transporter Type 1
External IDs
GeneCards: [1]
Orthologs
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Human
Mouse
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Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene.[1] GLUT1 facilitates the transport of glucose across the plasma membranes of mammalian cells.[2] This gene encodes a facilitative glucose transporter that is highly expressed in erythrocytes and endothelial cells, including cells of the blood–brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II.[3] GLUT1 accounts for 2 percent of the protein in the plasma membrane of erythrocytes.
Mutations in this gene can cause GLUT1 deficiency syndrome 1, GLUT1 deficiency syndrome 2, idiopathic generalized epilepsy 12, dystonia 9, and stomatin-deficient cryohydrocytosis.[4][5]
^Mueckler M, Caruso C, Baldwin SA, Panico M, Blench I, Morris HR, Allard WJ, Lienhard GE, Lodish HF (September 1985). "Sequence and structure of a human glucose transporter". Science. 229 (4717): 941–5. Bibcode:1985Sci...229..941M. doi:10.1126/science.3839598. PMID 3839598.
^Olson AL, Pessin JE (1996). "Structure, function, and regulation of the mammalian facilitative glucose transporter gene family". Annual Review of Nutrition. 16: 235–56. doi:10.1146/annurev.nu.16.070196.001315. PMID 8839927.
^ This article incorporates text from this source, which is in the public domain: "Entrez Gene: Transmembrane protein 70". Retrieved 2018-08-14.
^"SLC2A1 – Solute carrier family 2, facilitated glucose transporter member 1 – Homo sapiens (Human) – SLC2A1 gene & protein". www.uniprot.org. Retrieved 2018-08-27. This article incorporates text available under the CC BY 4.0 license.
^"UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.
Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that...
GLUT1 deficiency syndrome, also known as GLUT1-DS, De Vivo disease or Glucose transporter type 1 deficiency syndrome, is an autosomal dominant genetic...
subclasses. Class I comprises the well-characterized glucose transporters GLUT1-GLUT4. Class II comprises: GLUT5 (SLC2A5), a fructose transporter in enterocytes...
of glucose transporters; however, the most significant for study are GLUT1-4. GLUT1 and GLUT3 are located in the plasma membrane of cells throughout the...
a fetal skeletal muscle cell line, using a GLUT1 cDNA probe and shown to share 64.4% identity with GLUT1. Although GLUT3 was found to be expressed in...
that can only manage toe walking. Toe walking is a symptom in those with GLUT1 deficiency Syndrome. There are many health professionals who assess and...
gradient. GLUT1 is the most abundantly expressed of the family thought to maintain basal glucose transport in almost all cell types. GLUT1 levels, in...
the same cell membrane, is specific to one type or family of molecules. GLUT1 is a named carrier protein found in almost all animal cell membranes that...
phagocytosis of tumor cells. Utilizing a mouse model, they identified that both Glut1 and glucose metabolism increased in TANs found within a mouse who possessed...
at a higher rate. An analysis of mRNA levels of GLUT1 and GLUT4 in cardiac muscles show that GLUT1 plays a larger role in cardiac muscles than it does...
fourteen GLUT proteins. Class I GLUTs include GLUT1, one of the most studied isoforms, and GLUT2. GLUT1 is found in various tissues like the red blood...
they naturally mutate. For instance, erythrocyte-specific coexpression of GLUT1 with stomatin constitutes a compensatory mechanism in mammals that are unable...
glucose can no longer diffuse out of the cell. The glucose transporter GLUT1 is produced by most cell types and is of particular importance for nerve...
lesions cause abnormal electrochemical discharges that result in seizures GLUT1 deficiency syndrome Anorexia nervosa, bulimia nervosa, and other eating...
of the cell. One example of a uniport mediated transport protein is GLUT1. GLUT1 is a transmembrane protein, which means it spans the entire width of...
include genetic disorders such as Down syndrome, Fragile X syndrome and GLUT1 Deficiency Syndrome; childhood infections such as meningitis or encephalitis...
specialized cells, whereas the glucose transporters, the most notable being GLUT1, transport Vitamin C (in its oxidized form, DHA) in most cells, where recycling...
hypertension causes mesangial cells to stretch which causes induced expression of GLUT1 leading to increased cellular glucose. The repetition of stretching and...
import ascorbate across plasma membranes. The Hexose Transporter proteins GLUT1, GLUT3 and GLUT4 transfer only the oxydized dehydroascorbic acid (DHA) form...
hypoglycorrhacia]. Hypoglycorrhachia is associated with Glucose transporter type 1 GLUT1 deficiency syndrome (De Vivo disease). Perhaps a much more common example...
into cells via insulin-sensitive pathways (insulin regulated transporters GLUT1 and GLUT4). Instead, fructose is taken in by GLUT5. Fructose in muscles...
eye–head movements, termed aberrant gaze saccades, are an early symptom of GLUT1 deficiency syndrome in infancy.[non-primary source needed] When the brain...
membrane include, but are not limited to, glucose transporters, including GLUT1, and the proton-driven oligopeptide transporters PEPT1 and PEPT2. Melatonin...
Global Information
This article incorporates text from this source, which is in the public domain: "Entrez Gene: Transmembrane protein 70". Retrieved 2018-08-14.
This article incorporates text available under the CC BY 4.0 license.
