Glc_transpt_2IPR002440GLUT2Glucosamine/glucose uniporterGlut-2Glucose Transporter Type 2
External IDs
GeneCards: [1]
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Human
Mouse
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Glut2basal.png
Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes. It is the principal transporter for transfer of glucose between liver and blood[1] Unlike GLUT4, it does not rely on insulin for facilitated diffusion.
In humans, this protein is encoded by the SLC2A2 gene.[2][3]
^Gwyn W. Gould; Helen M. Thomas; Thomas J. Jess; Graeme I. Bell (May 1991). "Expression of human glucose transporters in Xenopus oocytes: kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms". Biochemistry. 30 (21): 5139–5145. doi:10.1021/bi00235a004. PMID 2036379.
^Froguel P, Zouali H, Sun F, Velho G, Fukumoto H, Passa P, Cohen D (July 1991). "CA repeat polymorphism in the glucose transporter GLUT 2 gene". Nucleic Acids Research. 19 (13): 3754. doi:10.1093/nar/19.13.3754-a. PMC 328421. PMID 1852621.
^Uldry M, Thorens B (February 2004). "The SLC2 family of facilitated hexose and polyol transporters" (PDF). Pflügers Archiv. 447 (5): 480–9. doi:10.1007/s00424-003-1085-0. PMID 12750891. S2CID 25539725.
Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein...
meal, the cell is signaled to move GLUT2 into membranes of the cells lining the intestines called enterocytes. With GLUT2 in place after a meal and the relative...
glucose to be transported into the cell by the glucose transport protein GLUT2, but is not recognized by the other glucose transporters. This explains...
high affinity for glucose and uptake from the bloodstream is constant. GLUT2 in contrast has a high Km value (15-20mM) and therefore a low affinity for...
the enterocyte across the basolateral membrane by either GLUT2 or GLUT5, although the GLUT2 transporter has a greater capacity for transporting fructose...
secretion (GSIS). There are four key pieces to the triggering pathway of GSIS: GLUT2 dependent glucose uptake, glucose metabolism, KATP channel closure, and...
which is not present in myocytes, and the free glucose exits the cell via GLUT2 facilitated diffusion channels in the hepatocyte cell membrane. Glycogenolysis...
enterocyte via the basolateral membrane (into the blood capillary) using GLUT2. Galactose uses the same transport system. Fructose, on the other hand,...
basolateral side of the intestinal epithelial cells via the glucose transporter GLUT2, as well uptake into liver cells, kidney cells, cells of the islets of Langerhans...
because it preferentially accumulates in beta cells through uptake via the GLUT2 glucose transporter. Alloxan, in the presence of intracellular thiols, generates...
continues to play a role in the regulation and expression of genes for insulin, GLUT2, glucokinase, and somatostatin. MODY 4 is so rare that only a single family...
models. In both cases, it is a cytotoxic analog of glucose that passes GLUT2 transport and accumulates in β-cells, causing their destruction. The chemically...
to changes in extracellular glucose. GP astrocytes possess high-capacity GLUT2-type glucose transporter proteins and appear to modulate the neuronal responses...
intestine (e.g., GLUT5), and to the basal membrane, contacting the blood (e.g., GLUT2). Improper absorption of these FODMAPS in the small intestine leaves them...
among others, the genes for insulin, the principal glucose transporter (GLUT2), and several proteins involved in glucose and mitochondrial metabolism...
phosphorylase-b kinase deficiency. GSD type XI (GSD 11): Fanconi-Bickel syndrome (GLUT2 deficiency), hepatorenal glycogenosis with renal Fanconi syndrome, no longer...
fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2". J. Nutr. Biochem. 15 (10): 630–7. doi:10.1016/j.jnutbio.2004.06.003. PMID 15542355...
diabetes mellitus, defect in glucose transport across the blood-brain barrier GLUT2, SLC2A2 low CNS glucose causing seizures, Fanconi-Bickel syndrome, Glycogen...
of glucose and fructose through the function of glucose transporter 2 (GLUT2) in sugar absorption. In addition, daily injections of myricetin into rats...
GLUT2. GLUT1 is found in various tissues like the red blood cells, brain, and blood-brain barrier and is responsible for basal glucose uptake. GLUT2 is...
blood-brain barrier. Fanconi-Bickel syndrome (GLUT2 deficiency, formally known as GSD-XI) is a deficiency of GLUT2, which is needed for the transport of glucose...
capacity than GLUT1 or GLUT4, as well as a higher glucose affinity than GLUT1, GLUT2 or GLUT4. This is significant as glucose levels surrounding the neurons...
and diabetes has been reported, including the involvement in GLUT1 and GLUT2 transporter expression in pancreatic β-cells and angiotensin-converting...
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