oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
isocitrate dehydrogenase activity
NAD binding
magnesium ion binding
metal ion binding
isocitrate dehydrogenase (NADP+) activity
protein homodimerization activity
Cellular component
mitochondrial inner membrane
cytosol
mitochondrial matrix
peroxisome
extracellular exosome
mitochondrion
Biological process
2-oxoglutarate metabolic process
glyoxylate cycle
isocitrate metabolic process
tricarboxylic acid cycle
NADP biosynthetic process
negative regulation of glial cell proliferation
negative regulation of glial cell migration
negative regulation of matrix metallopeptidase secretion
mitochondrion organization
carbohydrate metabolic process
NADP metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3418
269951
Ensembl
ENSG00000182054
ENSMUSG00000030541
UniProt
P48735
P54071
RefSeq (mRNA)
NM_002168 NM_001289910 NM_001290114
NM_173011
RefSeq (protein)
NP_001276839 NP_001277043 NP_002159
NP_766599
Location (UCSC)
Chr 15: 90.08 – 90.1 Mb
Chr 7: 79.74 – 79.77 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene.[5]
Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by the IDH2 gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.[5] Somatic mosaic mutations of this gene have also been found associated to Ollier disease and Maffucci syndrome.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000182054 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030541 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene. Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation...
inhibitor of isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2), which are mutated in several forms of cancer. In a phase-III-trial, it...
and secondary high-grade gliomas. Wang et al. pointed out that IDH1 and IDH2 mutant cells produce an excess metabolic intermediate, 2-hydroxyglutarate...
Mutations in the genes encoding for isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in 10–20% of patients with myelodysplastic syndrome, and confer a...
isocitrate dehydrogenase 2 (IDH2) gene, determined by an FDA-approved IDH2 companion diagnostic test. It is an inhibitor of IDH2. It was developed by Agios...
neoplasm. Cases in patients with Ollier disease has shown a link to IDH1, IDH2, and PTH1R gene mutations. Currently, there are no forms of treatment for...
inhibiting isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2), respectively. Ivosidenib is specific to acute myeloid leukemia (AML) and...
mutations include in the DNA demethylase TET2 and the metabolic enzymes IDH1 and IDH2, which lead to the generation of a novel oncometabolite, D-2-hydroxyglutarate...
while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and...
isozymes, the other two being IDH2 and IDH3, and encoded by one of five isocitrate dehydrogenase genes, which are IDH1, IDH2, IDH3A, IDH3B, and IDH3G. IDH1...
Astrocytomas carry a mutation in IDH1 or IDH2, whereas this mutation is not present in glioblastoma. Thus, IDH1 and IDH2 mutations are a useful tool to distinguish...
presence or absence of a targeted protein via staining. Mutations in IDH1 and IDH2 genes are commonly found in low-grade gliomas Loss of both IDH genes combined...
presence of IDH1 or IDH2 mutations and the codeletion of chromosome 1p and 19q arms. Interestingly, oligodendroglioma has a higher rate of IDH2 mutation than...
Pollock, Robin; O'Donnell, Paul; Grigoriadis, Anita (Jul 2011). "IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal...
apparent. Maffucci syndrome is most commonly caused by mutations in the IDH1 or IDH2 gene. In Ollier's disease, isolated enchondromas are present without the...
mutations occur in approximately 6 to 10% of the patients with AML, and IDH2 mutations occur in approximately 9 to 13% of those with AML, with unknown...
and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations". Acta Neuropathologica. 124 (5): 615–625. doi:10.1007/S00401-012-1031-3...
such as isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) can cause the inactivation of histone demethyltransferase which in turn...
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