PDK2 information

PDK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BTZ, 2BU2, 2BU5, 2BU6, 2BU7, 2BU8, 4MP2, 4MP7, 4MPC, 4MPE, 4MPN, 4V25, 4V26
Identifiers
Aliases	PDK2, PDHK2, PDKII, pyruvate dehydrogenase kinase 2
External IDs	OMIM: 602525 MGI: 1343087 HomoloGene: 68265 GeneCards: PDK2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,112,152 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,932,180 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; left ventricle; ; gastric mucosa; ; prefrontal cortex; ; nucleus accumbens; ; thoracic diaphragm; ; popliteal artery; ; right coronary artery; ; triceps brachii muscle; ; body of pancreas;
	Top expressed in
	interventricular septum; ; skeletal muscle tissue; ; myocardium of ventricle; ; digastric muscle; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; extraocular muscle; ; cardiac muscles; ; ankle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein homodimerization activity; kinase activity; ATP binding; pyruvate dehydrogenase (acetyl-transferring) kinase activity;
Cellular component	nucleoplasm; mitochondrial matrix; mitochondrion; mitochondrial pyruvate dehydrogenase complex; cytosol;
Biological process	phosphorylation; cellular response to reactive oxygen species; intrinsic apoptotic signaling pathway by p53 class mediator; glucose metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; cellular response to nutrient; insulin receptor signaling pathway; regulation of cellular ketone metabolic process; regulation of glucose metabolic process; glucose homeostasis; regulation of pH; protein phosphorylation; regulation of gluconeogenesis; carbohydrate metabolic process; regulation of calcium-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	5164
	18604
	ENSG00000005882
	ENSMUSG00000038967
	Q15119
	Q9JK42
	NM_002611; NM_001199898; NM_001199899; NM_001199900
	NM_133667; NM_001361915
	NP_001186827; NP_001186828; NP_001186829; NP_002602
	NP_598428; NP_001348844
	Wikidata
View/Edit Human	View/Edit Mouse

Pyruvate dehydrogenase kinase isoform 2 (PDK2) also known as pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial is an enzyme that in humans is encoded by the PDK2 gene.^[5]^[6] PDK2 is an isozyme of pyruvate dehydrogenase kinase.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005882 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038967 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Dec 1995). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". The Journal of Biological Chemistry. 270 (48): 28989–94. doi:10.1074/jbc.270.48.28989. PMID 7499431.
^ "Entrez Gene: PDK2 pyruvate dehydrogenase kinase, isozyme 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000005882 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038967 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7499431-5] Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Dec 1995). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". The Journal of Biological Chemistry. 270 (48): 28989–94. doi:10.1074/jbc.270.48.28989. PMID 7499431.

[entrez-6] "Entrez Gene: PDK2 pyruvate dehydrogenase kinase, isozyme 2".

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