Dihydrolipoyl transacetylase information

DLAT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FYC, 1Y8N, 1Y8O, 1Y8P, 2DNE, 2PNR, 2Q8I, 3B8K, 3CRK, 3CRL
Identifiers
Aliases	DLAT, DLTA, PDC-E2, PDCE2, dihydrolipoamide S-acetyltransferase, Dihydrolipoyl transacetylase, E2
External IDs	OMIM: 608770 MGI: 2385311 HomoloGene: 6814 GeneCards: DLAT
Gene location (Human)
Chr.	Chromosome 11 (human)
End	112,064,390 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	50,571,080 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; biceps brachii; ; thoracic diaphragm; ; vastus lateralis muscle; ; body of tongue; ; muscle of leg; ; gastrocnemius muscle; ; deltoid muscle; ; triceps brachii muscle; ; islet of Langerhans;
	Top expressed in
	digastric muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; interventricular septum; ; right ventricle; ; myocardium of ventricle; ; spermatocyte; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; dihydrolipoyllysine-residue acetyltransferase activity; protein binding; pyruvate dehydrogenase (NAD+) activity; acyltransferase activity; identical protein binding; dihydrolipoamide S-acyltransferase activity;
Cellular component	mitochondrial pyruvate dehydrogenase complex; myelin sheath; pyruvate dehydrogenase complex; mitochondrial matrix; mitochondrion;
Biological process	tricarboxylic acid cycle; regulation of acetyl-CoA biosynthetic process from pyruvate; sleep; pyruvate metabolic process; glucose metabolic process; metabolism; acetyl-CoA biosynthetic process from pyruvate; cellular nitrogen compound metabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1737
	235339
	ENSG00000150768
	ENSMUSG00000000168
	P10515
	Q8BMF4
	NM_001931
	NM_145614
NP_001922; NP_001358960; NP_001358961; NP_001358962; NP_001358963;
	NP_001358964; NP_001358965; NP_001358966; NP_001358967; NP_001358968; NP_001358969; NP_001358970; NP_001358971
	NP_663589
	Wikidata
View/Edit Human	View/Edit Mouse

Dihydrolipoyl transacetylase (or dihydrolipoamide acetyltransferase) is an enzyme component of the multienzyme pyruvate dehydrogenase complex. The pyruvate dehydrogenase complex is responsible for the pyruvate decarboxylation step that links glycolysis to the citric acid cycle. This involves the transformation of pyruvate from glycolysis into acetyl-CoA which is then used in the citric acid cycle to carry out cellular respiration.

There are three different enzyme components in the pyruvate dehydrogenase complex. Pyruvate dehydrogenase (EC 1.2.4.1) is responsible for the oxidation of pyruvate, dihydrolipoyl transacetylase (this enzyme; EC 2.3.1.12) transfers the acetyl group to coenzyme A (CoA), and dihydrolipoyl dehydrogenase (EC 1.8.1.4) regenerates the lipoamide. Because dihydrolipoyl transacetylase is the second of the three enzyme components participating in the reaction mechanism for conversion of pyruvate into acetyl CoA, it is sometimes referred to as E2.

In humans, dihydrolipoyl transacetylase enzymatic activity resides in the pyruvate dehydrogenase complex component E2 (PDCE2) that is encoded by the DLAT (dihydrolipoamide S-acetyltransferase) gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150768 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000168 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leung PS, Watanabe Y, Munoz S, Teuber SS, Patel MS, Korenberg JR, Hara P, Coppel R, Gershwin ME (1993). "Chromosome localization and RFLP analysis of PDC-E2: the major autoantigen of primary biliary cirrhosis". Autoimmunity. 14 (4): 335–40. doi:10.3109/08916939309079237. PMID 8102256.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150768 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000168 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8102256-5] Leung PS, Watanabe Y, Munoz S, Teuber SS, Patel MS, Korenberg JR, Hara P, Coppel R, Gershwin ME (1993). "Chromosome localization and RFLP analysis of PDC-E2: the major autoantigen of primary biliary cirrhosis". Autoimmunity. 14 (4): 335–40. doi:10.3109/08916939309079237. PMID 8102256.

Dihydrolipoyl transacetylase information

and 9 Related for: Dihydrolipoyl transacetylase information

Dihydrolipoyl transacetylase

Pyruvate dehydrogenase complex

E2

Oxidative decarboxylation

Lipoic acid

Pyruvate dehydrogenase deficiency

Pyruvate dehydrogenase lipoamide kinase isozyme 1

PDK2

E3 binding protein