RNA polymerase II core promoter sequence-specific DNA binding
Cellular component
cytoplasm
nucleus
nucleoplasm
nuclear speck
Biological process
apoptotic process
centrosome cycle
regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of protein kinase activity
signal transduction in response to DNA damage
response to stress
positive regulation of JNK cascade
regulation of cell cycle
cellular response to DNA damage stimulus
cellular response to mechanical stimulus
positive regulation of reactive oxygen species metabolic process
positive regulation of apoptotic process
cellular response to ionizing radiation
cell cycle
DNA repair
positive regulation of p38MAPK cascade
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1647
13197
Ensembl
ENSG00000116717
ENSMUSG00000036390
UniProt
P24522
P48316
RefSeq (mRNA)
NM_001924 NM_001199741 NM_001199742
NM_007836
RefSeq (protein)
NP_001186670 NP_001186671 NP_001915
NP_031862
Location (UCSC)
Chr 1: 67.69 – 67.69 Mb
Chr 6: 67.01 – 67.01 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000116717 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000036390 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (March 1991). "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Mol Cell Biol. 11 (2): 1009–16. doi:10.1128/MCB.11.2.1009. PMC 359769. PMID 1990262.
^Hollander MC, Alamo I, Jackman J, Wang MG, McBride OW, Fornace AJ Jr (December 1993). "Analysis of the mammalian gadd45 gene and its response to DNA damage". J Biol Chem. 268 (32): 24385–93. doi:10.1016/S0021-9258(20)80537-7. PMID 8226988.
^"Entrez Gene: GADD45A growth arrest and DNA-damage-inducible, alpha".
DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene. This gene is a member of a group of genes, the GADD45 genes, whose...
The Growth Arrest and DNA Damage or gadd45 genes, including GADD45A (originally termed gadd45) GADD45B (originally termed MyD118), and GADD45G (originally...
with GADD45A. GADD45G and GADD45A knockdowns are related to improper gastrulation, defective head growth, and shorter axes. GADD45G and GADD45A act redundantly...
Kovalsky O, Lung FD, Roller PP, Fornace AJ (2001). "Oligomerization of human Gadd45a protein". J. Biol. Chem. 276 (42): 39330–9. doi:10.1074/jbc.M105115200...
neurodegeneration. GADD45GIP1 has been shown to interact with GADD45G, GADD45B and GADD45A. GRCh38: Ensembl release 89: ENSG00000179271 – Ensembl, May 2017 GRCm38:...
in sarcomas. These include APC, CDKN1A, CDKN2A, CDKN2B, Ezrin, FGFR1, GADD45A, MGMT, STK3, STK4, PTEN, RASSF1A, WIF1, as well as several miRNAs. Expression...
cell to exit mitosis. Cyclin B1 has been shown to interact with Cdk1, GADD45A and RALBP1. One of the hallmarks of cancer is the lack of regulation in...
Lung FD, Roller PP, Fornace AJ (Oct 2001). "Oligomerization of human Gadd45a protein". The Journal of Biological Chemistry. 276 (42): 39330–9. doi:10...
repaired and then methylated by DNMTs. DNA damage response genes, such as GADD45A, recruit nuclear proteins Np95 to direct histone methyltransferase's towards...
described. MAP3K4 has been shown to interact with GADD45G, GADD45B and GADD45A. GRCh38: Ensembl release 89: ENSG00000085511 – Ensembl, May 2017 GRCm38:...
ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage". Molecular and Cellular Biology. 23 (20): 7305–14. doi:10...
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