Crystal structure of MSH2:MSH3 heterodimer in complex with DNA (PDB: 3THX). MSH2 and MSH3 bind to form MutSβ. This crystal structure shows MutSβ bound to DNA containing an insertion loop of three unpaired nucleotides.
somatic recombination of immunoglobulin gene segments
meiotic mismatch repair
removal of nonhomologous ends
mitotic recombination
reciprocal meiotic recombination
replication fork arrest
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4437
17686
Ensembl
ENSG00000113318
ENSMUSG00000014850
UniProt
P20585
P13705
RefSeq (mRNA)
NM_002439
NM_010829 NM_001311120
RefSeq (protein)
NP_002430
NP_001298049 NP_034959
Location (UCSC)
Chr 5: 80.65 – 80.88 Mb
Chr 13: 92.35 – 92.49 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatellites during DNA synthesis. Deficient capacity for MMR is found in approximately 15% of colorectal cancers, and somatic mutations in the MSH3 gene can be found in nearly 50% of MMR-deficient colorectal cancers.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000113318 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000014850 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gao JX, Park JM, Huang S, Tougeron D, Sinicrope FA (2013). "MSH3 Mismatch Repair Protein Regulates Sensitivity to Cytotoxic Drugs and a Histone Deacetylase Inhibitor in Human Colon Carcinoma Cells". PLOS ONE. 8 (5): e65369. Bibcode:2013PLoSO...865369P. doi:10.1371/journal.pone.0065369. ISSN 1932-6203. PMC 3665625. PMID 23724141.
Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically...
to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. MSH2 is involved in many different...
eukaryotes, MutS homologs form two major heterodimers: Msh2/Msh6 (MutSα) and Msh2/Msh3 (MutSβ). The MutSα pathway is involved primarily in base substitution and...
gland, and related to skin pigmentation DNA mismatch repair genes: MSH2 MSH3 MSH4 MSH5 MSH6 Multiple system atrophy Mycothiol, an unusual thiol that is...
genetic events, hypermutated tumors display mutated forms of ACVR2A, TGFBR2, MSH3, MSH6, SLC9A9, TCF7L2, and BRAF. The common theme among these genes, across...
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079...
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079...
"Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289 (9): 5664–73. doi:10.1074/jbc...
"Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease". J. Biol. Chem. 289 (9): 5664–73. doi:10.1074/jbc...
syndrome Several genes have been associated with polyposis, such as GREM1, MSH3, MLH3, NTHL1, RNF43 and RPS20. Familial adenomatous polyposis (FAP) is a...
The seven DNA mismatch repair proteins in humans are MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2. In addition, there are Exo1-dependent and Exo1-independent...
although hMSH2 itself can function as a homomultimer or as a heterodimer with hMSH3. Mismatches commonly occur as a result of DNA replication errors, genetic...
performed in DT40 cells upon removal of MSH3, an essential protein in MMR. The resulting microDNA from the DT40 MSH3-/- cell line had a higher enrichment...
The sanctuary is closed on Mondays. Traveling on the Wardha-Nagpur road MSH3, one must turn north at Seloo for Hingi and then to the visitor center at...
important new genetic modifier of disease progression in Huntington’s disease (MSH3, a mismatch repair protein), which has opened up new avenues of research...
instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079...
intermediate can avoid mismatch repair due to its affinity for the MSH-2-MSH3 complex, which stabilizes the hairpin instead of repairing it. In non-dividing...
of genetic mutations. Deficiency of DNA repair proteins PMS2, MLH1, MSH2, MSH3, MSH6 or BRCA2 can cause up to 100-fold increases in mutation frequency Epigenetic...
Global Information
