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Prokaryotic large ribosomal subunit information


Atomic structure of the 50S Subunit from Haloarcula marismortui. Proteins are shown in blue and the two RNA strands in orange and yellow.[1] The small patch of green in the center of the subunit is the active site.
Atomic structure of the 50S large subunit of the ribosome, facing the 30S small ribosomal subunit. Proteins are colored in blue and RNA in ochre. The active site, adenine 2486, is highlighted in red. Image created from PDB: 3CC2​ using PyMol

50S is the larger subunit of the 70S ribosome of prokaryotes, i.e. bacteria and archaea. It is the site of inhibition for antibiotics such as macrolides, chloramphenicol, clindamycin, and the pleuromutilins. It includes the 5S ribosomal RNA and 23S ribosomal RNA.

Despite having the same sedimentation rate, bacterial and archaeal ribosomes can be quite different.

  1. ^ Cite error: The named reference nissen was invoked but never defined (see the help page).

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Prokaryotic large ribosomal subunit

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the large subunit to fold; this process may take a period of time (5 minutes for beta-galactosidase[citation needed]). Prokaryotic small ribosomal subunit...

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Prokaryotic small ribosomal subunit

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The prokaryotic small ribosomal subunit, or 30S subunit, is the smaller subunit of the 70S ribosome found in prokaryotes. It is a complex of the 16S ribosomal...

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Ribosomal RNA

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ribosomes. Ribosomal RNA is transcribed from ribosomal DNA (rDNA) and then bound to ribosomal proteins to form small and large ribosome subunits. rRNA is...

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Ribosome

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components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA molecules and many ribosomal proteins (r-proteins)...

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23S ribosomal RNA

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have a significant function for tRNA binding in the P site of the large ribosomal subunit. These modification nucleotides in site P can inhibit peptidyl-tRNA...

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28S ribosomal RNA

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28S ribosomal RNA is the structural ribosomal RNA (rRNA) for the large subunit (LSU) of eukaryotic cytoplasmic ribosomes, and thus one of the basic components...

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16S ribosomal RNA

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16S ribosomal RNA (or 16S rRNA) is the RNA component of the 30S subunit of a prokaryotic ribosome (SSU rRNA). It binds to the Shine-Dalgarno sequence and...

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Ribosome biogenesis

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made up of two subunits – the large 60S subunit (which contains the 25S [in plants] or 28S [in mammals], 5.8S, and 5S rRNA and 46 ribosomal proteins) and...

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Eukaryotic ribosome

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mRNA, while the large subunit catalyzes peptide bond formation. Compared to their prokaryotic homologs, many of the eukaryotic ribosomal proteins are enlarged...

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Mitochondrial ribosomal protein L10

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L20

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L32

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L3

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L22

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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SSU rRNA

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subunit ribosomal ribonucleic acid (SSU rRNA) is the smaller of the two major RNA components of the ribosome. Associated with a number of ribosomal proteins...

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RNA

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transfer RNA (tRNA) molecules to deliver amino acids to the ribosome, where ribosomal RNA (rRNA) then links amino acids together to form coded proteins. It...

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Mitochondrial ribosomal protein L19

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Initiation factor

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43S ribosomal complex can bind and scan the mRNA for the start codon. During this process, the 60S ribosomal subunit binds and the large 80S ribosomal complex...

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Mitochondrial ribosomal protein L41

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L11

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Eukaryotic initiation factor

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followed by large 60S ribosomal subunit recruitment to form the 80S ribosome. There exist many more eukaryotic initiation factors than prokaryotic initiation...

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Mitochondrial ribosomal protein L12

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L30

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L4

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L39

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L24

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

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Mitochondrial ribosomal protein L15

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consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this...

Word Count : 620

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