Mitochondrial ribosomal protein L22 information

MRPL22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y
Identifiers
Aliases	MRPL22, L22mt, MRP-L22, MRP-L25, RPML25, HSPC158, mitochondrial ribosomal protein L22
External IDs	OMIM: 611835; MGI: 1333794; HomoloGene: 56664; GeneCards: MRPL22; OMA:MRPL22 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	154,969,411 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	58,070,391 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; left ventricle; ; right auricle; ; olfactory zone of nasal mucosa; ; islet of Langerhans; ; right ventricle; ; right adrenal gland; ; left testis; ; apex of heart; ; left adrenal gland;
	Top expressed in
	morula; ; proximal tubule; ; right kidney; ; adrenal gland; ; epiblast; ; blastocyst; ; embryo; ; neural tube; ; embryo; ; quadriceps femoris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	mitochondrial inner membrane; large ribosomal subunit; ribosome; mitochondrion; mitochondrial large ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis; ribosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	29093
	216767
	ENSG00000082515
	ENSMUSG00000020514
	Q9NWU5
	Q8BU88
	NM_014180; NM_001014990
	NM_175001
	NP_001014990; NP_054899
	NP_778166; NP_001390902
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.^[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000082515 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020514 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MRPL22 mitochondrial ribosomal protein L22".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000082515 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020514 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MRPL22 mitochondrial ribosomal protein L22".

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