Mitochondrial ribosomal protein L19 information

MRPL19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL19, L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15, mitochondrial ribosomal protein L19
External IDs	OMIM: 611832; MGI: 1926274; HomoloGene: 8851; GeneCards: MRPL19; OMA:MRPL19 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	75,690,851 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	81,942,939 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right adrenal gland; ; Skeletal muscle tissue of biceps brachii; ; left adrenal gland; ; rectum; ; right adrenal cortex; ; gingival epithelium; ; left adrenal cortex; ; islet of Langerhans; ; muscle of thigh;
	Top expressed in
	endocardial cushion; ; medullary collecting duct; ; epiblast; ; otic placode; ; migratory enteric neural crest cell; ; blastocyst; ; atrioventricular valve; ; atrium; ; renal corpuscle; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome;
Cellular component	mitochondrial inner membrane; ribosome; nuclear membrane; intracellular anatomical structure; nucleus; mitochondrion; mitochondrial large ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	9801
	56284
	ENSG00000115364
	ENSMUSG00000030045
	P49406
	Q9D338
	NM_014763
	NM_026490
	NP_055578
	NP_080766
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L19, mitochondrial is a protein that in humans is encoded by the MRPL19 gene.^[5]^[6]^[7]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115364 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030045 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
^ Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, Massinen S, Onkamo P, Warnke A, Griesemann H, Hoffmann P, Nopola-Hemmi J, Lyytinen H, Schulte-Korne G, Kere J, Nothen MM, Peyrard-Janvid M (Apr 2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia". Hum Mol Genet. 16 (6): 667–77. doi:10.1093/hmg/ddm009. PMID 17309879.
^ ^a ^b "Entrez Gene: MRPL19 mitochondrial ribosomal protein L19".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115364 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030045 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11543634-5] Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.

[pmid17309879-6] Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, Massinen S, Onkamo P, Warnke A, Griesemann H, Hoffmann P, Nopola-Hemmi J, Lyytinen H, Schulte-Korne G, Kere J, Nothen MM, Peyrard-Janvid M (Apr 2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia". Hum Mol Genet. 16 (6): 667–77. doi:10.1093/hmg/ddm009. PMID 17309879.

[entrez-7] "Entrez Gene: MRPL19 mitochondrial ribosomal protein L19".

Mitochondrial ribosomal protein L19 information

and 5 Related for: Mitochondrial ribosomal protein L19 information

Mitochondrial ribosomal protein L19

L19

Ribosomal protein

Rickettsiaceae

Rickettsia