Mitochondrial ribosomal protein L12 information

MRPL12
Identifiers
Aliases	MRPL12, 5c5-2, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12, mitochondrial ribosomal protein L12
External IDs	OMIM: 602375; MGI: 1926273; HomoloGene: 2212; GeneCards: MRPL12; OMA:MRPL12 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,707,517 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; mucosa of transverse colon; ; left ventricle; ; right auricle; ; muscle of thigh; ; right lobe of liver; ; gastrocnemius muscle; ; mucosa of esophagus; ; human kidney; ; skeletal muscle tissue;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; intracellular anatomical structure; mitochondrial large ribosomal subunit; mitochondrion;
Biological process	positive regulation of transcription, DNA-templated; mitochondrial transcription; mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	6182
	56282
	ENSG00000262814
	ENSMUSG00000039640
	P52815
	Q9DB15
	NM_002949
	NM_027204
	NP_002940
	NP_081480
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L12, mitochondrial is a protein that in humans is encoded by the MRPL12 gene.^[4]^[5]^[6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000262814 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marty L, Fort P (Jun 1996). "A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein". J Biol Chem. 271 (19): 11468–76. doi:10.1074/jbc.271.19.11468. PMID 8626705.
^ Marty L, Taviaux S, Fort P (Jul 1997). "Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12". Genomics. 41 (3): 453–7. doi:10.1006/geno.1997.4691. PMID 9169145.
^ ^a ^b "Entrez Gene: MRPL12 mitochondrial ribosomal protein L12".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000262814 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8626705-4] Marty L, Fort P (Jun 1996). "A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein". J Biol Chem. 271 (19): 11468–76. doi:10.1074/jbc.271.19.11468. PMID 8626705.

[pmid9169145-5] Marty L, Taviaux S, Fort P (Jul 1997). "Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12". Genomics. 41 (3): 453–7. doi:10.1006/geno.1997.4691. PMID 9169145.

[entrez-6] "Entrez Gene: MRPL12 mitochondrial ribosomal protein L12".

Mitochondrial ribosomal protein L12 information

and 5 Related for: Mitochondrial ribosomal protein L12 information

Mitochondrial ribosomal protein L12

Ribosomal protein

5S ribosomal RNA

UBE2E3

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