Mitochondrial ribosomal protein L17 information

MRPL17
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQM, 3J7Y, 3J9M
Identifiers
Aliases	MRPL17, L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26, mitochondrial ribosomal protein L17
External IDs	OMIM: 611830; MGI: 1351608; HomoloGene: 32526; GeneCards: MRPL17; OMA:MRPL17 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,683,340 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,460,306 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; apex of heart; ; anterior pituitary; ; left adrenal gland; ; right ventricle; ; right adrenal gland; ; left adrenal cortex; ; gonad; ; right adrenal cortex; ; muscle of thigh;
	Top expressed in
	blastocyst; ; embryo; ; embryo; ; yolk sac; ; morula; ; right kidney; ; otic placode; ; lip; ; muscle of thigh; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; protein domain specific binding;
Cellular component	ribosome; intracellular anatomical structure; mitochondrion; mitochondrial large ribosomal subunit; mitochondrial inner membrane;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis; mitochondrial genome maintenance;
	Sources:Amigo / QuickGO
Orthologs
	63875
	27397
	ENSG00000158042
	ENSMUSG00000030879
	Q9NRX2
	Q9D8P4
	NM_022061
	NM_025301
	NP_071344
	NP_079577
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.^[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158042 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030879 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MRPL17 mitochondrial ribosomal protein L17".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158042 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030879 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MRPL17 mitochondrial ribosomal protein L17".

Mitochondrial ribosomal protein L17 information

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