Practolol information

Practolol
Clinical data
ATC code	C07AB01 (WHO) ;
Identifiers
	IUPAC name (RS)-N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide;
CAS Number	6673-35-4 ;
PubChem CID	4883;
IUPHAR/BPS	555;
DrugBank	DB01297 ;
ChemSpider	4715 ;
UNII	SUG9176GRW;
KEGG	D05587 ;
ChEBI	CHEBI:258351 ;
ChEMBL	ChEMBL6995 ;
CompTox Dashboard (EPA)	DTXSID0021179 ;
ECHA InfoCard	100.027.012
Chemical and physical data
Formula	C14H22N2O3
Molar mass	266.341 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(Nc1ccc(OCC(O)CNC(C)C)cc1)C;
	InChI InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17) ; Key:DURULFYMVIFBIR-UHFFFAOYSA-N ;
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Practolol (Eraldin, Dalzic, Praktol, Cardiol, Pralon, Cordialina, Eraldina, Teranol) is a selective beta blocker (beta-1 blocker) that has been used in the emergency treatment of cardiac arrhythmias. Practolol is no longer used as it is highly toxic despite the similarity of its chemical formula to propranolol. After its introduction, keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage developed in 27 patients as an adverse reaction to practolol. Rashes, nasal and mucosal ulceration, fibrous or plastic peritonitis, pleurisy, cochlear damage, and secretory otitis media also occurred in some cases. Three patients suffered profound visual loss though most retained good vision. Symptoms and signs improved on withdrawal of the drug, but reduction of tear secretion persisted in most patients.^[1]

^ Wright P (March 1975). "Untoward effects associated with practolol administration: oculomucocutaneous syndrome". British Medical Journal. 1 (5958): 595–598. doi:10.1136/bmj.1.5958.595. PMC 1672788. PMID 1125623.

[1] Wright P (March 1975). "Untoward effects associated with practolol administration: oculomucocutaneous syndrome". British Medical Journal. 1 (5958): 595–598. doi:10.1136/bmj.1.5958.595. PMC 1672788. PMID 1125623.

Practolol information

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Practolol

Oculomucocutaneous syndrome

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Propranolol

Adrenaline

Tizanidine

Buspirone

Tamsulosin

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Hydroxyzine

Prochlorperazine

Clonidine

Norepinephrine

Haloperidol

Tyrosine

C14H22N2O3

Guanfacine

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Xylazine

Phenylephrine

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Vortioxetine

Tricyclic antidepressant

Clinical data

ATC code	C07AB01 (WHO)
Identifiers
IUPAC name (RS)-N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide
CAS Number	6673-35-4^Y
PubChem CID	4883
IUPHAR/BPS	555
DrugBank	DB01297^Y
ChemSpider	4715^Y
UNII	SUG9176GRW
KEGG	D05587^N
ChEBI	CHEBI:258351^Y
ChEMBL	ChEMBL6995^Y
CompTox Dashboard (EPA)	DTXSID0021179
ECHA InfoCard	100.027.012
Chemical and physical data
Formula	C₁₄H₂₂N₂O₃
Molar mass	266.341 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(Nc1ccc(OCC(O)CNC(C)C)cc1)C
InChI InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)^Y Key:DURULFYMVIFBIR-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)