positive regulation of fast-twitch skeletal muscle fiber contraction
negative regulation of striated muscle contraction
calcium ion import
positive regulation of endoplasmic reticulum calcium ion concentration
ion transport
response to endoplasmic reticulum stress
maintenance of mitochondrion location
ion transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of striated muscle contraction
apoptotic mitochondrial changes
relaxation of skeletal muscle
negative regulation of endoplasmic reticulum calcium ion concentration
positive regulation of mitochondrial calcium ion concentration
calcium ion transport
calcium ion transmembrane transport
cellular calcium ion homeostasis
proton transmembrane transport
calcium ion import into sarcoplasmic reticulum
positive regulation of cardiac muscle cell contraction
positive regulation of ATPase-coupled calcium transmembrane transporter activity
positive regulation of calcium ion import into sarcoplasmic reticulum
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
487
11937
Ensembl
ENSG00000196296
ENSMUSG00000030730
UniProt
O14983
Q8R429
RefSeq (mRNA)
NM_173201 NM_001286075 NM_004320
NM_007504
RefSeq (protein)
NP_001273004 NP_004311 NP_775293
NP_031530
Location (UCSC)
Chr 16: 28.88 – 28.9 Mb
Chr 7: 126.05 – 126.06 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) also known as Calcium pump 1, is an enzyme that in humans is encoded by the ATP2A1 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000196296 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030730 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
ATP2A1 is also implicated in myotonic dystrophy type 1. ATP2A1 SERCA pumps were very strongly down regulated in amyotrophic lateral sclerosis. ATP2A1...
Most cases of BD are inherited through autosomal recessive mutations in ATP2A1, where each copy of the affected individual's gene contain a mutation. The...
SERCA1-3, which are expressed at various levels in different cell types. ATP2A1 – SERCA1 ATP2A2 – SERCA2 ATP2A3 – SERCA3 There are additional post-translational...