Oxprenolol information

Oxprenolol
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth
ATC code	C07AA02 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	20-70%
Metabolism	Liver
Elimination half-life	1-2hours
Excretion	Kidney ; Lactic (in lactiferous females)
Identifiers
	IUPAC name (RS)-1-[2-(Allyloxy)phenoxy]-3-(isopropylamino)propan-2-ol;
CAS Number	6452-71-7 ;
PubChem CID	4631;
IUPHAR/BPS	7255;
DrugBank	DB01580 ;
ChemSpider	4470 ;
UNII	519MXN9YZR;
KEGG	D08318 ;
ChEMBL	ChEMBL546 ;
CompTox Dashboard (EPA)	DTXSID1043835 ;
ECHA InfoCard	100.026.598
Chemical and physical data
Formula	C15H23NO3
Molar mass	265.353 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O(c1ccccc1OC\C=C)CC(O)CNC(C)C;
	InChI InChI=1S/C15H23NO3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17H,1,9-11H2,2-3H3 ; Key:CEMAWMOMDPGJMB-UHFFFAOYSA-N ;
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Oxprenolol (brand names Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris, abnormal heart rhythms and high blood pressure.

Oxprenolol is a lipophilic beta blocker which passes the blood–brain barrier more easily than water-soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than beta blockers with more hydrophilic molecules such as atenolol, sotalol and nadolol.^[1]

Oxprenolol is a potent beta blocker and should not be administered to asthmatics under any circumstances due to their low beta levels as a result of depletion due to other asthma medication, and because it can cause irreversible, often fatal, airway failure and inflammation.^[2]

^ McDevitt DG (December 1987). "Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs". European Heart Journal. 8. 8 Suppl M: 9–14. doi:10.1093/eurheartj/8.suppl_M.9. PMID 2897304.
^ Williams IP, Millard FJ (February 1980). "Severe asthma after inadvertent ingestion of oxprenolol". Thorax. 35 (2): 160. doi:10.1136/thx.35.2.160. PMC 471246. PMID 7376124.

[1] McDevitt DG (December 1987). "Comparison of pharmacokinetic properties of beta-adrenoceptor blocking drugs". European Heart Journal. 8. 8 Suppl M: 9–14. doi:10.1093/eurheartj/8.suppl_M.9. PMID 2897304.

[2] Williams IP, Millard FJ (February 1980). "Severe asthma after inadvertent ingestion of oxprenolol". Thorax. 35 (2): 160. doi:10.1136/thx.35.2.160. PMC 471246. PMID 7376124.

Oxprenolol information

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Clinical data

AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	AU: C
Routes of administration	By mouth
ATC code	C07AA02 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	20-70%
Metabolism	Liver
Elimination half-life	1-2hours
Excretion	Kidney Lactic (in lactiferous females)
Identifiers
IUPAC name (RS)-1-[2-(Allyloxy)phenoxy]-3-(isopropylamino)propan-2-ol
CAS Number	6452-71-7^Y
PubChem CID	4631
IUPHAR/BPS	7255
DrugBank	DB01580^N
ChemSpider	4470^Y
UNII	519MXN9YZR
KEGG	D08318^Y
ChEMBL	ChEMBL546^Y
CompTox Dashboard (EPA)	DTXSID1043835
ECHA InfoCard	100.026.598
Chemical and physical data
Formula	C₁₅H₂₃NO₃
Molar mass	265.353 g·mol⁻¹
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES O(c1ccccc1OC\C=C)CC(O)CNC(C)C
InChI InChI=1S/C15H23NO3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17H,1,9-11H2,2-3H3^Y Key:CEMAWMOMDPGJMB-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)