Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric),[5] is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). The murine ortholog is Spp1. Osteopontin is a SIBLING (glycoprotein) that was first identified in 1986 in osteoblasts.
The prefix osteo- indicates that the protein is expressed in bone, although it is also expressed in other tissues. The suffix -pontin is derived from "pons," the Latin word for bridge, and signifies osteopontin's role as a linking protein. Osteopontin is an extracellular structural protein and therefore an organic component of bone.
The gene has 7 exons, spans 5 kilobases in length and in humans it is located on the long arm of chromosome 4 region 22 (4q1322.1). The protein is composed of ~300 amino acids residues and has ~30 carbohydrate residues attached, including 10 sialic acid residues, which are attached to the protein during post-translational modification in the Golgi apparatus. The protein is rich in acidic residues: 30-36% are either aspartic or glutamic acid.
^ abcGRCh38: Ensembl release 89: ENSG00000118785 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029304 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and...
accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides), and small inhibitory molecules (such as pyrophosphate)...
specialized proteins in much smaller quantities, including osteocalcin and osteopontin, which compose the organic matrix of bone. In organized groups of disconnected...
matrix protein, uses the third. Some other bone matrix proteins such as osteopontin and bone sialoprotein use both the first and the second. Direct activation...
Molecular mechanisms such as: juvista, ribosomal s6 kinase (RSK), and osteopontin were investigated. In 2011, the scientific literature highlighted stress...
Jeffrey J.; Bui, Khanh Huy; McKee, Marc D. (2 March 2018). "Nanostructure, osteopontin, and mechanical properties of calcitic avian eggshell". Science Advances...
mineralization and renal phosphate reabsorption. The bone and dentin protein osteopontin (OPN) which inhibits mineralization in the skeleton and in teeth is a...
The Ras/RAF/MEK/ERK pathway is also implicated in overexpression of osteopontin (OPN), which is important for maintenance of the hematopoietic stem cell...
development of praziquantel in the 1980s. Post-treatment monitoring Osteopontin (OPN) is a promising tool for monitoring praziquantel efficacy and post-treatment...
protein), Tamm–Horsfall protein, glycosaminoglycans, uropontin (a form of osteopontin), nephrocalcin (an acidic glycoprotein), prothrombin F1 peptide, and...
protein, haptoglobin-alpha, OVX1, mesothelin, lysophosphatidic acid, osteopontin, and fibroblast growth factor 23. Use of blood test panels may help in...
though similar experiments. Philip, S; Bulbule, A; Kundu, GC (2001). "Osteopontin stimulates tumor growth and activation of pro-matrix metalloproteinase-2...
remodelling by degenerating the bone matrix proteins such as type I collagen, osteopontin, and osteonectin. Defective function of cathepsin K therefore results...
to hyaluronic acid and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 function is controlled...
Kazanecki, CC; Uzwiak, DJ; Denhxxardt, DT (1 November 2007). "Control of osteopontin signaling and function by post-translational phosphorylation and protein...
Chambers AF (November 2001). "The functional and clinical roles of osteopontin in cancer and metastasis". Curr. Mol. Med. 1 (5): 621–32. doi:10.2174/1566524013363339...
methods thus improving the survival prospects for patients. The serum osteopontin level might be useful in screening asbestos-exposed people for mesothelioma...
specific amino acid motif Arg-Gly-Asp in bone matrix proteins, such as osteopontin. The osteoclast releases hydrogen ions through the action of carbonic...
cytokine, called osteopontin, may be able to aid in axon regeneration by exposing its integrin receptor binding sites. Osteopontin secretion may be able...
chondroitin sulfate, as well as non-collagenous proteins such as osteocalcin, osteopontin or bone sialoprotein. Collagen consists of strands of repeating units...
biomarkers, such as kidney injury molecule-1 (KIM-1), clusterin, and osteopontin (OPN), and in humans, insulin-like growth factor binding protein 7 (IGFBP7)...
OPN may stand for: Osteopontin, a glycoprotein secreted by osteoblasts Object Process Network, a simulation model meta-language Optics & Photonics News...
present in significantly greater quantities in alpha motor neurons. Osteopontin, a protein also expressed in bones, hence the "osteo-" prefix, is a marker...
many matrix proteins, including fibronectin, fibrinogen, vitronectin, osteopontin, and several other adhesive extracellular matrix proteins. The discovery...
uterine milk. Important uterine milk proteins are glycodelin-A, and osteopontin. Some secretory components from the uterine glands are taken up by the...
Global Information
