3D rendered CT scan of bone metastases of the hip bone, in a 60 year old woman with parotid gland cancer. Large lesions are seen on the ilium on the more distant side. Involvement of the vertebral column has caused a compression fracture.
Specialty
Oncology
Bone metastasis, or osseous metastatic disease, is a category of cancer metastases that result from primary tumor invasions into bones. Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing sarcoma are rare; the most common bone tumor is a metastasis.[1] Bone metastases can be classified as osteolytic, osteoblastic, or both. Unlike hematologic malignancies which originate in the blood and form non-solid tumors, bone metastases generally arise from epithelial tumors and form a solid mass inside the bone. Bone metastases, especially in a state of advanced disease, can cause severe pain, characterized by a dull, constant ache with periodic spikes of incident pain.[2]
^MedlinePlus Overview bonecancer
^Jimenez-Andrade JM, Mantyh WG, Bloom AP, Ferng AS, Geffre CP, Mantyh PW (June 2010). "Bone cancer pain". Annals of the New York Academy of Sciences. 1198 (1): 173–81. Bibcode:2010NYASA1198..173J. doi:10.1111/j.1749-6632.2009.05429.x. PMC 5642911. PMID 20536932.
Bonemetastasis, or osseous metastatic disease, is a category of cancer metastases that result from primary tumor invasions into bones. Bone-originating...
apoptosis of tumour cells. Bone is a common site of metastasis in cancers such as breast, prostate and lung cancer. In osteolytic bone metastases, tumour cells...
cancer of the bone or metastasis, location of bone inflammation and fractures (that may not be visible in traditional X-ray images), and bone infection (osteomyelitis)...
that exhibit bone fragility. Bisphosphonates are used to treat osteoporosis, osteitis deformans (Paget's disease of the bone), bonemetastasis (with or without...
In breast cancer, spinal-cord compression occurs when a bonemetastasis or spinal metastasis begins to push on the spinal cord, resulting in inflammation...
cases of bone cancer is systemic radioisotope therapy, where the radioisotopes target sections of the bone specifically undergoing metastasis. In the case...
cancer causes hypercalcemia is via local osteolysis due to metastasis to bone. Tumor bonemetastasis releases local cytokines including IL-6, IL-8, IL-11,...
Antonarakis, Emmanuel S. (October 2012). "Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastases". Cancer Letters. 323 (2):...
VH includes but is not limited to hemangioblastoma, lymphangioma, bonemetastasis, Ewing Sarcoma, and spinal dural arteriovenous fistula. Treatment for...
Metastasis is common in the late stages of cancer and it can occur via the blood or the lymphatic system or both. The typical steps in metastasis are...
most bone cancers that are secondary having developed as a metastasis from another cancer. Bone sarcomas are rare, and mostly affect the legs. The other...
Radium-223 as an Enabler for Novel Combinations to Treat Patients with BoneMetastasis". International Journal of Molecular Sciences. 20 (16): 3899. doi:10...
a bone that has been made weak by some underlying disease is called pathological fracture. e.g., a fracture through a bone weakened by metastasis. Osteoporosis...
behavior of these cells in bone does not fully mimic clinical human disease. It is well established that human PCa bonemetastasis form osteoblastic lesions...
A bone tumor is an abnormal growth of tissue in bone, traditionally classified as noncancerous (benign) or cancerous (malignant). Cancerous bone tumors...
classification (tumor, node, metastasis). This is based on the size of the primary tumor, lymph node involvement, and distant metastasis. TMN evaluation allows...
carcinomatosis, leptomeningeal disease (LMD), leptomeningeal metastasis, meningeal metastasis and meningeal carcinomatosis. It occurs with cancers that are...
Lymph node metastasis is the spread (metastasis) of cancer cells into a lymph node. Lymph node metastasis is different from malignant lymphoma. Lymphoma...
metastasis of basal-like breast cancer to the lungs showed that repression of Wnt/β-catenin signaling can prevent EMT, which can inhibit metastasis....
likelihood of an underlying problem, investigations for cancer with metastasis to the bone, multiple myeloma, Cushing's disease and other above-mentioned causes...
acquired and hereditary. Osteogenic bonemetastasis caused by carcinoma of prostate and breast Paget's disease of bone Myelofibrosis (primary disorder or...
treatment of bonemetastasis from cancer. The radioisotopes travel selectively to areas of damaged bone, and spare normal undamaged bone. Isotopes commonly...
[ACTH]). Bonemetastasis is uncommon. Hindgut NETs are argentaffin negative and rarely secrete 5-HT, 5-HTP, or any other vasoactive peptides. Bone metastases...
Metastasis in common iliac lymph nodes M (Distant metastasis) MX Distant metastasis cannot be assessed M0 No distant metastasis M1 Distant metastasis...
spread of certain brain tumors outside the central nervous system, e.g. bonemetastasis of glioblastoma.) Primary brain tumors generally are invasive (i.e...
an immune response The PC3 cell line was established in 1979 from bonemetastasis of grade IV of prostate cancer in a 62-year-old Caucasian male. These...
to design tumors models and investigate malignant transformation and metastasis, 3D cultures can provide aggerate tool for understanding changes, interactions...
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