Chemical compound
Orforglipron
3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one
CAS Number PubChem CID UNII Formula C 48 H 48 F 2 N 10 O 5 Molar mass 882.974 g·mol−1 3D model (JSmol)
C[C@H]1C[C@]1(C2=NOC(=O)N2)N3C4=C(C=C(C=C4)[C@H]5CCOC(C5)(C)C)C=C3C(=O)N6CCC7=NN(C(=C7[C@@H]6C)N8C=CN(C8=O)C9=C(C1=C(C=C9)N(N=C1)C)F)C1=CC(=C(C(=C1)C)F)C
InChI=1S/C48H48F2N10O5/c1-25-18-32(19-26(2)40(25)49)60-42(58-16-15-57(46(58)63)37-11-10-36-33(41(37)50)24-51-55(36)7)39-28(4)56(14-12-34(39)53-60)43(61)38-21-31-20-29(30-13-17-64-47(5,6)23-30)8-9-35(31)59(38)48(22-27(48)3)44-52-45(62)65-54-44/h8-11,15-16,18-21,24,27-28,30H,12-14,17,22-23H2,1-7H3,(H,52,54,62)/t27-,28-,30-,48-/m0/s1
Key:USUWIEBBBWHKNI-KHIFEHGGSA-N
Orforglipron (LY-3502970 ) is a non-peptide glucagon-like peptide-1 receptor agonist developed as a weight loss drug by Eli Lilly and Company.[1] [2] It is easier to produce than GLP-1 agonists on the market in 2023 and is expected to be cheaper.[3]
^ Pratt E, Ma X, Liu R, Robins D, Coskun T, Sloop KW, et al. (June 2023). "Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1b, multicentre, blinded, placebo-controlled, randomized, multiple-ascending-dose study in people with type 2 diabetes". Diabetes, Obesity & Metabolism . doi:10.1111/dom.15150 . PMID 37264711. S2CID 259022851.
^ Wharton S, Blevins T, Connery L, Rosenstock J, Raha S, Liu R, et al. (June 2023). "Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity". The New England Journal of Medicine . doi:10.1056/NEJMoa2302392. PMID 37351564.
^ Sidik, Saima (2023). "Beyond Ozempic: brand-new obesity drugs will be cheaper and more effective". Nature . 619 (7968): 19–19. doi:10.1038/d41586-023-02092-9.
Last Update: 2024-02-08T19:31:17Z
Orforglipron (LY-3502970) is a non-peptide glucagon-like peptide-1 receptor agonist developed as a weight loss drug by Eli Lilly and Company. It is easier...
Word Count : 171
Last Update: 2023-12-08T06:48:17Z
enzymes which could indicate potential for liver toxicity. Danuglipron Orforglipron US 10676465, Aspnes GE, et al., "GLP-1 receptor agonists and uses thereof"...
Word Count : 83
Last Update: 2023-12-08T06:47:49Z
reported adverse events were nausea, diarrhea, and vomiting. Lotiglipron Orforglipron Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria...
Word Count : 190
Last Update: 2024-05-18T22:56:18Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 5418
Last Update: 2024-03-22T03:35:15Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 262
Last Update: 2024-04-07T06:23:31Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 1512
Last Update: 2024-05-19T21:56:02Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 3481
Last Update: 2024-04-11T15:05:59Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 1622
Last Update: 2024-05-14T04:52:47Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 3387
Last Update: 2024-03-24T06:24:34Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 1575
Last Update: 2024-05-20T05:15:44Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 4939
Last Update: 2024-05-16T17:42:47Z
still-unclear vaginal seeding interventions (15 June), phase 2 trialed orforglipron against obesity (23 June), mice-tested gene-therapy against hearing loss...
Word Count : 44458
Last Update: 2023-12-20T19:33:54Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 781
Last Update: 2024-04-13T05:07:30Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 1890
Last Update: 2024-05-08T15:03:31Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 2518
Last Update: 2023-12-20T19:33:15Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 888
Last Update: 2024-01-13T20:04:40Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 909
Last Update: 2024-04-27T22:39:33Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 2133
Last Update: 2024-04-12T03:54:44Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 694
Last Update: 2024-04-19T03:01:23Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 2909
Last Update: 2024-03-21T00:37:13Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 2379
Last Update: 2024-04-13T05:09:46Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 2074
Last Update: 2024-04-13T14:42:31Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 2571
Last Update: 2024-04-27T11:23:32Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 1943
Last Update: 2024-04-26T18:01:42Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 275
Last Update: 2024-03-04T00:40:46Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 691
Last Update: 2024-05-15T19:52:12Z
Albiglutide‡ Danuglipron† Dulaglutide Exenatide Liraglutide Lixisenatide Orforglipron § Semaglutide Taspoglutide† DPP-4 inhibitors/"gliptins" Alogliptin Anagliptin...
Word Count : 2665