Canagliflozin, sold under the brand name Invokana among others, is a medication used to treat type 2 diabetes.[2] It is used together with exercise and diet.[2] It is not recommended in type 1 diabetes.[2] It is taken by mouth.[2]
Common side effects include vaginal yeast infections, nausea, constipation, and urinary tract infections.[2] Serious side effects may include low blood sugar, Fournier's gangrene, leg amputation, kidney problems, high blood potassium, and low blood pressure.[2] Diabetic ketoacidosis may occur despite nearly normal blood sugar levels.[2] Use in pregnancy and breastfeeding is not recommended.[1] Canagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor.[2] It works by increasing the amount of glucose lost in the urine.[2]
Canagliflozin was approved for medical use in the United States, in the European Union, and in Australia in 2013.[2][3][4][5] It is on the World Health Organization's List of Essential Medicines.[6]
^ ab"Canagliflozin (Invokana) Use During Pregnancy". Drugs.com. Retrieved 6 April 2019.
^ abcdefghij"Canagliflozin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 6 April 2019.
^Cite error: The named reference FDA approval was invoked but never defined (see the help page).
^Cite error: The named reference Invokana EPAR was invoked but never defined (see the help page).
^"Australian Public Assessment Report for Canagliflozin (as hemihydrate)" (PDF). Therapeutic Goods Administration (TGA). 31 March 2014. Retrieved 28 August 2020.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Canagliflozin, sold under the brand name Invokana among others, is a medication used to treat type 2 diabetes. It is used together with exercise and diet...
this class had been approved or were under development. In studies on canagliflozin, a member of this class, the medication was found to enhance blood sugar...
tubule lining, so the first step continues to happen. Gliflozins such as canagliflozin inhibit renal glucose reabsorption, and are used in diabetes mellitus...
malignancy. Fournier gangrene is a rare side effect of SGLT2 inhibitors (canagliflozin, dapagliflozin, and empagliflozin), which increase the excretion of...
to recommend they be stopped temporarily before scheduled surgery. Canagliflozin, dapagliflozin, and empagliflozin should each be stopped at least three...
with cardiovascular disease (which liraglutide, empagliflozin, and canagliflozin are all FDA approved to treat). Concerns about the safety of rosiglitazone...
Administration (FDA) in the United States; dapagliflozin, canagliflozin and empagliflozin. Canagliflozin was the first SGLT-2 inhibitor that was approved by...
repaglinide A10BD15 Metformin and dapagliflozin A10BD16 Metformin and canagliflozin A10BD17 Metformin and acarbose A10BD18 Metformin and gemigliptin A10BD19...
combination of bempedoic acid and ezetimibe) Other Canalia (teneligliptin, canagliflozin) (available only in Japan) Evoxac (cevimeline hydrochloride) Injectafer...
insulin glargine, including quality-assured biosimilars are alternatives Canagliflozin and dapagliflozin are alternatives Glibenclamide not suitable above...
urine.[citation needed] SGLT-2 inhibitor drugs like dapagliflozin and canagliflozin have recently been approved for lowering blood sugar levels in patients...
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