Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes.[7] In the United Kingdom it is listed as less preferred than metformin or a sulfonylurea.[8] It is taken by mouth.[7] It is also available in the fixed-dose combination medication sitagliptin/metformin (Janumet, Janumet XR).[7]
Common side effects include headaches, swelling of the legs, and upper respiratory tract infections.[7] Serious side effects may include angioedema, low blood sugar, kidney problems, pancreatitis, and joint pain.[7] Whether use in pregnancy or breastfeeding is safe is unclear.[9] It is in the dipeptidyl peptidase-4 (DPP-4) inhibitor class and works by increasing the production of insulin and decreasing the production of glucagon by the pancreas.[7]
Sitagliptin was developed by Merck & Co. and approved for medical use in the United States in 2006.[7] In 2021, it was the 83rd most commonly prescribed medication in the United States, with more than 8million prescriptions.[10][11] It is available as a generic medication in Canada but not the United States.[12][13]
^"Product monograph brand safety updates". Health Canada. February 2024. Retrieved March 24, 2024.
^"Januvia- sitagliptin tablet, film coated". DailyMed. Archived from the original on October 27, 2021. Retrieved October 15, 2021.
^"Zituvio- sitagliptin tablet". DailyMed. November 1, 2023. Retrieved December 25, 2023.
^"Zituvio- sitagliptin tablet". DailyMed. November 1, 2023. Retrieved December 25, 2023.
^"Januvia EPAR". European Medicines Agency. September 17, 2018. Archived from the original on October 23, 2021. Retrieved October 15, 2021.
^ abHerman GA, Stevens C, van Dyck K, Bergman A, Yi B, De Smet M, et al. (December 2005). "Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses". Clinical Pharmacology and Therapeutics. 78 (6): 675–688. doi:10.1016/j.clpt.2005.09.002. PMID 16338283. S2CID 20935646.
^ abcdefg"Sitagliptin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on March 4, 2016. Retrieved March 3, 2019.
^Cite error: The named reference BNF76 was invoked but never defined (see the help page).
^"Sitagliptin Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on March 6, 2019. Retrieved March 3, 2019.
^"The Top 300 of 2021". ClinCalc. Archived from the original on January 15, 2024. Retrieved January 14, 2024.
^"Sitagliptin - Drug Usage Statistics". ClinCalc. Retrieved January 14, 2024.
^"Generic Januvia Availability". Drugs.com. Retrieved December 1, 2023.
^"JAMP Pharma Group receives Health Canada approval for PrJAMP Sitagliptin, a new generic alternative for the treatment of type 2 diabetes" (Press release). JAMP Pharma. January 6, 2023. Retrieved June 19, 2023 – via Newswire.
Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. In the United Kingdom it is...
incretins and various combinations. Sitagliptin patent expired in July 2022, leading to launch of generic sitagliptin brands . This lowered the cost of...
for use as a monotherapy and as a fixed dose combination with either sitagliptin or with metformin. In the European Union, it was approved in March 2018...
twice daily, sitagliptin and rosiglitazone. In a randomized controlled trial (RCT) comparing liraglutide, glargine, glimepiride, and sitagliptin (all added...
Milicevic Z (August 2014). "Efficacy and safety of dulaglutide versus sitagliptin after 52 weeks in type 2 diabetes in a randomized controlled trial (AWARD-5)"...
pioglitazone A10BD06 Glimepiride and pioglitazone A10BD07 Metformin and sitagliptin A10BD08 Metformin and vildagliptin A10BD09 Pioglitazone and alogliptin...
does not appear worse than sitagliptin or glimepiride in reducing HbA1c levels, while canagliflozin maybe better than sitagliptin and glimiperide in decreasing...
(July 2009). "Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2...
blood glucose levels. DPP-4 inhibitors combined with metformin include a sitagliptin/metformin combination (Janumet), a saxagliptin/metformin combination...
Exenatide 2 mg compared to insulin glargine, exenatide 10 μg twice daily, sitagliptin and pioglitazone. Exenatide, lead to greater weight loss than glucagon-like...
metformin and 0.8% for sitagliptin with metformin, hence the efficacy of gemigliptin is found to be comparable to sitagliptin. ·Gemigliptin was shown...
August 2016. "Steglatro (ertugliflozin), Steglujan (ertugliflozin and sitagliptin), Segluromet (ertugliflozin and metformin hydrochloride) Tablets". U...
for UK SPC for sitagliptin phosphate monohydrate Register Extract for IE SPC for sitagliptin Register Extract for NL SPC for sitagliptin Register Extract...