A scanning electron microscope image of NETs engulfing fungal cells (Candida albicans) in an infected mouse lung. (Click on image for more details.)[1]Fluorescent image of cultivated neutrophils isolated from venous blood of human with Alzheimer Disease. Sample was treated with Hoechst 33342 dye that is used to stain DNA. The picture shows the release of DNA by a neutrophil as foggy area in the center of the view field indicating the spontaneous activation of neutrophil extracellular traps (NETs) formation in AD patients that is not usually observed in healthy mates. Magnification x40.
Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens.[2] Neutrophils are the immune system's first line of defense against infection and have conventionally been thought to kill invading pathogens through two strategies: engulfment of microbes and secretion of anti-microbials. In 2004, a novel third function was identified: formation of NETs. NETs allow neutrophils to kill extracellular pathogens while minimizing damage to the host cells.[3] Upon in vitro activation with the pharmacological agent phorbol myristate acetate (PMA), Interleukin 8 (IL-8) or lipopolysaccharide (LPS), neutrophils release granule proteins and chromatin to form an extracellular fibril matrix known as NET through an active process.[2]
^Urban, Constantin F.; Ermert, David; Schmid, Monika; Abu-Abed, Ulrike; Goosmann, Christian; Nacken, Wolfgang; Brinkmann, Volker; Jungblut, Peter R.; Zychlinsky, Arturo; Levitz, Stuart M. (30 October 2009). "Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans". PLOS Pathogens. 5 (10): e1000639. doi:10.1371/journal.ppat.1000639. PMC 2763347. PMID 19876394.
Neutrophilextracellulartraps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens. Neutrophils...
These neutrophilextracellulartraps (NETs) comprise a web of fibers composed of chromatin and serine proteases that trap and kill extracellular microbes...
destroys bacteria and host tissue. It also localizes to neutrophil extracellulartraps (NETs), via its high affinity for DNA, an unusual property for serine...
biodiversity. Neutrophilextracellulartraps (NETs) are networks of extracellular fibers, primarily composed of DNA, which allow neutrophils, a type of white...
efficient production and release of neutrophilextracellulartraps (NETs) from the neutrophils to trap and kill extracellular pathogens. Despite these characteristics...
cells includes breaking down extracellular DNA (ecDNA) excreted by apoptosis, necrosis, and neutrophilextracellulartraps (NET) of cells to help reduce...
them. This process characterizes neutrophils as a type of phagocyte. Neutrophils contain neutrophilextracellulartraps (NETs), composed of granule and...
allows the pathogen group A Streptococcus to escape killing in neutrophilextracellulartraps". Current Biology. 16 (4): 396–400. Bibcode:2006CBio...16..396B...
Theological Seminary (NETS), an evangelical seminary in Israel Neutrophilextracellulartraps Singh Program in Networked & Social Systems Engineering (NETS)...
Planck Institute for Infection Biology. His research focuses on NeutrophilExtracellularTraps (NETs) which he discovered together with Volker Brinkmann, and...
Neutrophils are recruited early in the process of venous thrombi formation. They release pro-coagulant granules and neutrophilextracellulartraps (NETs)...
processes such as platelet aggregation and the formation of neutrophilextracellulartraps. E. coli exposed to hypochlorous acid lose viability in less...
(C5L2) mediates the formation of neutrophilextracellulartraps and release of cytotoxic histones to the extracellular space, which is believed to act...
before they or their neutrophilextracellulartraps are phagocytized by the macrophages. When at the site, the first wave of neutrophils, after the process...
as neutrophilextracellulartraps (NETs). Composed mainly of DNA, NETs cause death by a process called netosis – after the pathogens are trapped in NETs...
as effectively as sulfasalazine. Neutrophilextracellulartraps and the resulting degradation of the extracellular matrix have been reported in the colon...
erythematosus preventing macrophages and monocytes from degrading neutrophilextracellulartraps and immune complexes. The failure to degrade internalized immune...
interface between the endocrine and nervous systems Neutrophilextracellulartraps, networks of extracellular fibers that bind pathogens Norepinephrine transporter...
environmental factors lead to the accumulation of neutrophilextracellulartraps (NET) releasing neutrophils in the lungs. This increased release of NETs have...
invaders, then hit them with a deadly oxidative blast, forming neutrophilextracellulartraps (NETs).[citation needed] This results in catastrophic immune...
process to be combatted. It includes the creation of NETs or neutrophilextracellulartraps that are composed of DNA wrapped around histones and proteins...
neutrophil function is believed to play a role in the pathogenesis of bronchiectasis. Neutrophilextracellulartraps (NETs), which are extracellular fibers...
of DNA by a neutrophil as foggy area in the center of the view field indicating the spontaneous activation of neutrophilextracellulartraps formation in...
respond to vascular injury. Also her lab has been studying NETs (NeutrophilExtracellularTraps) for more than a decade. In 2015, research from the lab shed...
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