Deoxyribonuclease (DNase, for short) refers to a group of glycoprotein endonucleases which are enzymes that catalyze the hydrolytic cleavage of phosphodiester linkages in the DNA backbone, thus degrading DNA. The role of the DNase enzyme in cells includes breaking down extracellular DNA (ecDNA) excreted by apoptosis, necrosis, and neutrophil extracellular traps (NET) of cells to help reduce inflammatory responses that otherwise are elicited. A wide variety of deoxyribonucleases are known and fall into one of two families (DNase I or DNase II), which differ in their substrate specificities, chemical mechanisms, and biological functions. Laboratory applications of DNase include purifying proteins when extracted from prokaryotic organisms. Additionally, DNase has been applied as a treatment for diseases that are caused by ecDNA in the blood plasma. Assays of DNase are emerging in the research field as well.
Deoxyribonuclease (DNase, for short) refers to a group of glycoprotein endonucleases which are enzymes that catalyze the hydrolytic cleavage of phosphodiester...
Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. DNase I is a nuclease that cleaves...
Deoxyribonuclease IV (phage-T4-induced) (EC 3.1.21.2, endodeoxyribonuclease IV (phage T4-induced), E. coli endonuclease IV, endodeoxyribonuclease, redoxyendonuclease...
Deoxyribonuclease X (EC 3.1.22.5, Escherichia coli endodeoxyribonuclease, Escherichia coli endodeoxyribonuclease X) is an enzyme. This enzyme catalyses...
Deoxyribonuclease II (EC 3.1.22.1, DNase II, pancreatic DNase II, deoxyribonucleate 3'-nucleotidohydrolase, pancreatic DNase II, acid deoxyribonuclease...
Type II site-specific deoxyribonuclease-like Structure of the homodimeric restriction enzyme EcoRI (cyan and green cartoon diagram) bound to double stranded...
EcoRI (pronounced "eco R one") is a restriction endonuclease enzyme isolated from species E. coli. It is a restriction enzyme that cleaves DNA double helices...
Deoxyribonuclease V (EC 3.1.21.7, endodeoxyribonuclease V, DNase V, Escherichia coli endodeoxyribonuclease V) is an enzyme. This enzyme catalyses the...
Aspergillus deoxyribonuclease K1 (EC 3.1.22.2, Aspergillus DNase K1) is an enzyme. This enzyme catalyses the following chemical reaction Endonucleolytic...
exonuclease V, E. coli exonuclease V, gene recBC endoenzyme, RecBC deoxyribonuclease, gene recBC DNase, gene recBCD enzymes) is an enzyme of E. coli that...
Deoxyribonuclease 2 beta is a protein that in humans is encoded by the DNASE2B gene. The protein encoded by this gene shares considerable sequence similarity...
from mannitol + Acid from sucrose + Nitrate reduction + (to nitrite) Deoxyribonuclease, 25 °C + Lipase + Pigment some biovars produce red Catalase production...
spreading factor) breaks down hyaluronic acid and helps in spreading it. Deoxyribonuclease, which breaks down the DNA, protects S. aureus from neutrophil extracellular...
same reason in the débridement of infected wounds. Hyaluronidase, deoxyribonuclease, lecithinase, leukocidin, protease, lipase, and hemolysin are also...
tracheobronchoplasty, and tracheostomy. The role of the nebulised recombinant human deoxyribonuclease (rhDNase) remains inconclusive. Tracheal collapse for the condition...
like hyaluronidase, lipase, collagenase, elastase, ribonuclease, deoxyribonuclease also play an important role in preventing the spread of infection...
Bibcode:1995Sci...269..656N. doi:10.1126/science.7624794. PMID 7624794. Deoxyribonuclease+BamHI at the U.S. National Library of Medicine Medical Subject Headings...
It is particularly effective for Gram-positive bacteria. b. DNase (Deoxyribonuclease): DNase degrades DNA present in the lysate, reducing its viscosity...
Deoxyribonuclease gamma is an enzyme that in humans is encoded by the DNASE1L3 gene. This gene encodes a member of the DNase family. The protein hydrolyzes...
chemical mediators, such as eosinophil peroxidase, ribonuclease (RNase), deoxyribonucleases (DNase), lipase, plasminogen, and major basic protein. These mediators...
treated in ambulatory settings is not known. Inhaled recombinant human deoxyribonuclease (rhDNase), an enzyme that digests the DNA that contributes to mucus...
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