negative regulation of transcription by RNA polymerase II
defense response to fungus
proteolysis
response to lipopolysaccharide
positive regulation of immune response
protein catabolic process
defense response to bacterium
phagocytosis
neutrophil-mediated killing of fungus
negative regulation of inflammatory response
response to UV
leukocyte migration
positive regulation of smooth muscle cell proliferation
leukocyte migration involved in inflammatory response
positive regulation of leukocyte tethering or rolling
antimicrobial humoral response
neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1991
50701
Ensembl
ENSG00000277571 ENSG00000197561
ENSMUSG00000020125
UniProt
P08246
Q3UP87
RefSeq (mRNA)
NM_001972
NM_015779
RefSeq (protein)
NP_001963
NP_056594
Location (UCSC)
Chr 19: 0.85 – 0.86 Mb
Chr 10: 79.72 – 79.72 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Neutrophil elastase (EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil, elaszym, serine elastase, subtype human leukocyte elastase (HLE)) is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Neutrophil elastase is secreted by neutrophils during inflammation, and destroys bacteria and host tissue.[5] It also localizes to neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases.[6]
As with other serine proteinases it contains a charge relay system composed of the catalytic triad of histidine, aspartate, and serine residues that are dispersed throughout the primary sequence of the polypeptide but that are brought together in the three dimensional conformation of the folded protein. The gene encoding neutrophil elastase, ELA2, consists of five exons. Neutrophil elastase is closely related to other cytotoxic immune serine proteases, such as the granzymes and cathepsin G. It is more distantly related to the digestive CELA1.[6]
The neutrophil form of elastase (EC 3.4.21.37) is 218 amino acids long, with two asparagine-linked carbohydrate chains (see glycosylation). It is present in azurophil granules in the neutrophil cytoplasm. There appear to be two forms of neutrophil elastase, termed IIa and IIb.
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020125 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Belaaouaj A, Kim KS, Shapiro SD (August 2000). "Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase". Science. 289 (5482): 1185–8. Bibcode:2000Sci...289.1185B. doi:10.1126/science.289.5482.1185. PMID 10947984.
^ abThomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J (June 2014). "Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins". J. Immunol. 192 (11): 5390–7. doi:10.4049/jimmunol.1303296. PMC 4041364. PMID 24771851.
and 26 Related for: Neutrophil elastase information
connective tissue. The neutrophil form breaks down the Outer membrane protein A (OmpA) of E. coli and other Gram-negative bacteria. Elastase also has the important...
neutrophilic parasites. In alpha 1-antitrypsin deficiency, the important neutrophilelastase is not adequately inhibited by alpha 1-antitrypsin, leading to excessive...
dominant and mostly caused by heterozygous mutations in the ELANE gene (neutrophilelastase). Neutropenia can be acute (temporary) or chronic (long lasting)...
corroborated that NETs contain proteins from azurophilic granules (neutrophilelastase, cathepsin G and myeloperoxidase), specific granules (lactoferrin)...
(ovalbumin related serpins) founded by ovalbumin. MNEI (monocyte/neutrophilelastase inhibitor) is the mouse orthologue of human SerpinB1. SerpinB1 is...
seminal fluids. SLPI inhibits human leukocyte elastase, human cathepsin G, human trypsin, neutrophilelastase, and mast cell chymase. X-ray crystallography...
associated with more severe bronchiectasis. Neutrophilelastase, which is an extracellular protein secreted by neutrophils to destroy pathogens as well as host...
research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophilelastase. It is used in the treatment of acute respiratory failure and preliminary...
aflatoxin damaged liver cells and bile duct cells are removed by neutrophilelastase and by involvement of immune system mediators such as CCL-2 or MCP-1...
of Littré. Smegma contains cathepsin B, lysozymes, chymotrypsin, neutrophilelastase and cytokines, which aid the immune system. According to Wright,...
related to other immune serine proteases, such as neutrophilelastase and the granzymes. As a neutrophil serine protease, was first identified as degradative...
apocrine glands, which secrete cathepsin B, lysozyme, chymotrypsin, neutrophilelastase, and hormones such as androsterone. The first four substances have...
days. However, bonds P3-P4 and P1'-P2' can be rapidly cleaved by neutrophilelastase and the bacterial enzyme thermolysin, respectively, resulting in...
their active site. Examples include thrombin, trypsin, and human neutrophilelastase. Serpins act as irreversible, suicide inhibitors by trapping an intermediate...
Elaszym may refer to one of two enzymes: Pancreatic elastaseNeutrophilelastase This disambiguation page lists articles associated with the title Elaszym...
immune system, inhibit neutrophilelastase strongly while ecotin from the plant pathogen Pantoea citrea inhibits neutrophilelastase 1000-fold less potently...
multifunctional inflammatory mediator. The genes encoding this protein, neutrophilelastase 2, and proteinase 3 are in a cluster located at chromosome 19pter...
alveoli is broken down by an imbalance between the production of neutrophilelastase (elevated by cigarette smoke) and alpha-1 antitrypsin (the activity...
deficiency. This eventually leads to emphysema from unregulated neutrophilelastase activity in the lung tissue. The alpha-1 fraction does not disappear...
damage response involves the proteolysis of type XVII collagen by neutrophilelastase in response to the DNA damage in the hair follicle stem cells. Proteolysis...
"Characterization of two azurphil granule proteases with active-site homology to neutrophilelastase". The Journal of Biological Chemistry. 265 (4): 2038–41. doi:10...
to result in decreased superoxide production in neutrophils, as well as declines in neutrophilelastase activity. This results in an increase in predisposition...
(non-pathogenic antibody blocker of AQP4-IgG binding), sivelestat (neutrophilelastase inhibitor), and eculizumab (complement inhibitor). There is little...
growth. Tumor infiltrating neutrophils have recently been thought to adjust tumor growth and invasiveness. Neutrophilelastase is shown to degrade IRS-1...
damage response involves the proteolysis of type XVII collagen by neutrophilelastase in response to DNA damage in hair follicle stem cells. Proteolysis...
Global Information
