structure of the two amino-terminal domains of human intercellular adhesion molecule-1, icam-1
Identifiers
Symbol
ICAM_N
Pfam
PF03921
Pfam clan
CL0011
InterPro
IPR013768
SCOP2
1zxq / SCOPe / SUPFAM
Membranome
219
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.[1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces.
^Gahmberg CG, Tolvanen M, Kotovuori P (April 1997). "Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands". Eur. J. Biochem. 245 (2): 215–32. doi:10.1111/j.1432-1033.1997.00215.x. PMID 9151947.
and 26 Related for: Intercellular adhesion molecule information
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barrier Contribute to the spermatogonial stem cell niche The intercellularadhesionmolecules ICAM-1 and soluble ICAM-1 have antagonistic effects on the...
adenosine; inhibition of T cell activation and suppression of intercellularadhesionmolecule expression by T cells; selective down-regulation of B cells;...
mechanism of the anti-inflammatory activity of ruscogenin: role of intercellularadhesionmolecule-1 and nuclear factor-kappaB". Journal of Pharmacological Sciences...
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with Intracellular Trafficking and N-Linked Glycosylation of IntercellularAdhesionMolecule-1". Biological and Pharmaceutical Bulletin. 41 (12): 1757–1768...
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