Global InformationICAM4 information
| Intercellular Adhesion Molecule-4 (Landsteiner-Wiener blood group system) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ICAM-4 | ||||||
| Alt. symbols | LW | ||||||
| NCBI gene | 3386 | ||||||
| HGNC | 5347 | ||||||
| OMIM | 111250 | ||||||
| RefSeq | NM_001039132 | ||||||
| UniProt | Q14773 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.2-cen | ||||||
| |||||||
The LW blood system was first described by Landsteiner and Wiener in 1940.[1] It was often confused with the Rh system, not becoming a separate antigen system until 1982. The LW and RhD antigens are genetically independent though they are phenotypically related and the LW antigen is expressed more strongly on RhD positive cells than on RhD negative cells. In most populations, the antithetical LW antigens, LWa and LWb are present as very high and very low frequency, respectively.[1][2][3]
- ^ a b Daniels G (2002). Human Blood Groups (2nd ed.). Malden, Mass.: Blackwell Science. ISBN 978-0-632-05646-0. OCLC 48435824.
- ^ Klein HG, Mollison PL, Anstee DJ (2005). Mollison's Blood Transfusion in Clinical Medicine (11th ed.). Oxford: Blackwell. ISBN 978-0-632-06454-0. OCLC 60348837.
- ^ Hoffbrand AV, Pettit JE, Moss PA (2006-10-31). Essential Haematology (5th ed.). Oxford: Wiley-Blackwell. ISBN 978-1-4051-3649-5. OCLC 70402356.