negative regulation of cell-cell adhesion mediated by cadherin
signal transduction involved in regulation of gene expression
negative regulation of apoptotic process
stem cell differentiation
positive regulation of cell population proliferation
positive regulation of stem cell proliferation
positive regulation of transcription by RNA polymerase II
leukocyte migration
cell-cell adhesion via plasma-membrane adhesion molecules
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4072
17075
Ensembl
ENSG00000119888
ENSMUSG00000045394
UniProt
P16422
Q99JW5
RefSeq (mRNA)
NM_002354
NM_008532
RefSeq (protein)
NP_002345
NP_032558
Location (UCSC)
Chr 2: 47.35 – 47.39 Mb
Chr 17: 87.94 – 87.96 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell–cell adhesion in epithelia.[5] EpCAM is also involved in cell signaling,[6] migration,[7] proliferation, and differentiation.[8] Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E.[9] Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000119888 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000045394 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO (April 1994). "Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule". The Journal of Cell Biology. 125 (2): 437–46. doi:10.1083/jcb.125.2.437. PMC 2120036. PMID 8163559.
^Maetzel D, Denzel S, Mack B, Canis M, Went P, Benk M, et al. (February 2009). "Nuclear signalling by tumour-associated antigen EpCAM". Nature Cell Biology. 11 (2): 162–71. doi:10.1038/ncb1824. PMID 19136966. S2CID 8616872.
^Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, et al. (August 2004). "EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy". Cancer Research. 64 (16): 5818–24. doi:10.1158/0008-5472.CAN-04-0754. PMID 15313925.
^Litvinov SV, van Driel W, van Rhijn CM, Bakker HA, van Krieken H, Fleuren GJ, Warnaar SO (March 1996). "Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation". The American Journal of Pathology. 148 (3): 865–75. PMC 1861708. PMID 8774141.
^Münz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O (July 2004). "The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation". Oncogene. 23 (34): 5748–58. doi:10.1038/sj.onc.1207610. PMID 15195135. S2CID 32348616.
^Armstrong A, Eck SL (2003). "EpCAM: A new therapeutic target for an old cancer antigen". Cancer Biology & Therapy. 2 (4): 320–6. doi:10.4161/cbt.2.4.451. PMID 14508099.
and 21 Related for: Epithelial cell adhesion molecule information
Celladhesionmolecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular...
Celladhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process...
transport. Cell junctions are especially abundant in epithelial tissues. Combined with celladhesionmolecules and extracellular matrix, cell junctions...
(July 2009). Mullins, Mary C (ed.). "The EpithelialCellAdhesionMolecule EpCAM Is Required for Epithelial Morphogenesis and Integrity during Zebrafish...
to aid in the diagnosis of basal cell carcinoma (BCC). It is an antibody to EpCAM (epithelialcelladhesionmolecule). BerEp4 has a high sensitivity and...
(epithelial celladhesionmolecule, ESA, TROP1) is hemophilic Ca2+-independent celladhesionmolecule expressed on the basolateral surface of most epithelial cells...
same adhesionmolecule can sort out. The molecules responsible for adhesion are called celladhesionmolecules (CAMs). Several types of celladhesion molecules...
transport of molecules across the epithelial sheet. How epithelialcells generate and maintain polarity remains unclear, but certain molecules have been...
A junctional adhesionmolecule (JAM) is a protein that is a member of the immunoglobulin superfamily, and is expressed in a variety of different tissues...
as celladhesion, ion conductivity, and cell signalling and serve as the attachment surface for several extracellular structures, including the cell wall...
mesothelium consists of a single layer of flattened to cuboidal cells forming the epithelial lining of the serous cavities of the body including the peritoneal...
monoclonal antibody which is used to target tumor cells. It binds to the epithelialcelladhesionmolecule (EpCAM - CD326), with the intent to trigger antibody-dependent...
other molecules into or out of the cell. Paracellular permeability depends on transport through the spaces that exist between epithelialcells. It is...
hydrophilic molecules. As such they are unable to diffuse freely across the bi-lipid layer of the plasma membrane, so their action is mediated by a cell membrane...
healthy cells and transplanted tissues, diseased cells, or invading organisms. Included in the glycocalyx are cell-adhesionmolecules that enable cells to...
(named for "calcium-dependent adhesion") are celladhesionmolecules important in forming adherens junctions that let cells adhere to each other. Cadherins...
Basal celladhesionmolecule, also known as Lutheran antigen, is a plasma membrane glycoprotein that in humans is encoded by the BCAM gene. BCAM has also...
cytokines. Many types of cancer cells carry EpCAM (epithelialcelladhesionmolecule) on their surface. By binding to such a cell via one arm, to a T lymphocyte...
Global Information
